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DR647MS) and counterstained with DAPI (blue; Lunaphore Catalog # DR100). Specific staining was localized to the cytoplasm. Protocol available in COMET™ Panel Builder." class="big_lightbox" target="_blank">
VC001) or the HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
VC001) or the HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
HAF018). A specific band was detected for Cytokeratin 17 at approximately 53 kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1." class="big_lightbox" target="_blank">
Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).
![Multiplex Immunofluorescence Cytokeratin 17 Antibody (1080235) [Unconjugated]](http://images.novusbio.com/images/mab11571_human-cytokeratin-17-mab-clone-1080235-multiplex-immunofluorescence-639216252674238694.png)
![Immunohistochemistry Cytokeratin 17 Antibody (1080235) [Unconjugated]](http://images.novusbio.com/images/antibody/mab11571_human-cytokeratin-17-mab-clone-1080235-immunohistochemistry-237202410468.jpg)
![Immunohistochemistry Cytokeratin 17 Antibody (1080235) [Unconjugated]](http://images.novusbio.com/images/antibody/mab11571_human-cytokeratin-17-mab-clone-1080235-immunohistochemistry-237202410558.jpg)
![Western Blot Cytokeratin 17 Antibody (1080235) [Unconjugated]](http://images.novusbio.com/images/antibody/mab11571_human-cytokeratin-17-mab-clone-1080235-western-blot-2382024132636..jpg)
![Immunocytochemistry Cytokeratin 17 Antibody (1080235) [Unconjugated]](http://images.novusbio.com/images/antibody/mab11571_human-cytokeratin-17-mab-clone-1080235-immunocytochemistry-2372024135910..jpg)
![Simple Western Cytokeratin 17 Antibody (1080235) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab11571_human-cytokeratin-17-mab-clone-1080235-simple-western-238202413304.jpg)
