Cyclin E2 Antibody (718916) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC
• Clone: 718916
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Cyclin E2 Antibody (718916) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human Cyclin E2
  Met1-Gln140
  Accession # O96020
• Specificity: Detects human Cyclin E2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cyclin E2 Antibody (718916) [Alexa Fluor® 647]

• CCNE2
• CYCE2
• Cyclin E2
• G1/S-specific cyclin E2
• G1/S-specific cyclin-E2

Background

Cyclin E2, also known as CCNE2, is an approximately 45-50 kDa protein that associates with the kinase Cdk2. This complex phosphorylates multiple substrates involved in regulation of cell cycle progression and the initiation of DNA replication. Cyclin E2 is required for G1/S phase progression and cell cycle reentry from G0 phase. Cyclin E2 most highly expressed in testis, thymus, and brain and is frequently upregulated in cancer. Cyclin E2 contains two cyclin box folds (amino acids 141-231 and amino acids 241-361). An alternate splice form lacks 45 amino acids (aa) within the first cyclin box fold. Within aa 1-140, human Cyclin E2 shares 90% aa sequence identity with mouse and rat Cyclin E2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.