CXCL15/Lungkine Antibody (96708) [Alexa Fluor® 405]

• Reactivity: Mu
• Applications: WB, ELISA(Cap), ELISA(Det)
• Clone: 96708
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 405

CXCL15/Lungkine Antibody (96708) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant mouse CXCL15/Lungkine
  Gln26-Ala167
  Accession # Q9WVL7
• Specificity: Detects mouse CXCL15/Lungkine in ELISAs and Western blots. In sandwich immunoassays, no cross-reactivity or interference with recombinant mouse (rm) CXCL13, recombinant human (rh) CXCL13, rhCXCL5, rhCXCL8, rmMIP-2, recombinant rat CINC
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL15/Lungkine Antibody (96708) [Alexa Fluor® 405]

• CXCL15
• Lungkine
• Scyb15
• Weche

Background

Mouse Lungkine/CXCL15 (1), also named WECHE (2), is a member of the ELR motif-containing CXC chemokines. The cDNA of mouse Lungkine encodes a protein of 166 amino acids (aa) with a 25 aa predicted signal peptide and a 141 aa mature protein with an extremely long C‑terminal tail that protrudes beyond the chemokine fold. Mouse Lungkine shares 35% aa sequence identity with human CXCL5 and 31% identity with human CXCL8. The gene for mouse Lungkine has been mapped to chromosome 5. By Northern blot and in situ hybridization, Lungkine transcripts are only specifically detected in the adult and fetal lung, and its expression is up‑regulated under inflammatory conditions (1). Lungkine protein is secreted into bronchoalveolar space and is involved in lung-specific neutrophils trafficking (1). Studies from Lungkine knock out mice suggests that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace (3). Lungkine is also chemotactic for bone marrow progenitor cells and modulates hematopoietic cell differentiation (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.