CRHBP Antibody [Alexa Fluor® 700]

• Reactivity: Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 700

CRHBP Antibody [Alexa Fluor® 700] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse CRHBP
  Tyr25-Leu322
  Accession # Q60571
• Specificity: Detects mouse CRHBP in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 70% cross-reactivity with recombinant human CRHBP is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CRHBP Antibody [Alexa Fluor® 700]

• corticotropin releasing hormone binding protein
• corticotropin-releasing factor-binding protein
• Corticotropin-releasing hormone-binding protein
• CRFBP
• CRFBPcorticotropin releasing hormone-binding protein
• CRF-BPCRF-binding protein
• CRHBP
• CRH-BP

Background

Mouse CRHBP is a 37 kDa, monomeric CRH-binding glycoprotein that is secreted by cells of the rodent adrenal, medulla, cortical neurons and astrocytes, and prolactin positive cells of the pituitary. The mature molecule is 298 amino acids (aa) in length and contains six intrachain disulfide bonds. It binds CRH and CRH-like peptides, either serving as an antagonist for CRH binding to CRH receptor 1, or as a coreceptor for CRH binding to CRH receptor 2. Mature mouse CRHBP shares 94%, 87%, 85% and 80% aa sequence identity with rat, human, canine and bovine CRHBP, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.