COPS4 Antibody

Product Discontinued

COPS4 Antibody Summary

• Immunogen: Synthetic peptide: AAVRQDLAQLMNS representing the N-Terminus of the human protein (residues 3-15), according to NP_057213.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: COPS4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Peptide ELISA 1:8000
• Application Notes: Approx. 40kDa and 55kDa bands observed in human skeletal muscle lysates at 1.5ug of primary. Please note that the band we observe is different from the predicted size of approx. 47kDa according to NP_057213. Currently we cannot find an explanation for this in the literature. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any splice variants/modified forms been reported?
• Control:

  COPS4 Overexpression Lysate

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for COPS4 Antibody

• COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
• COP9 signalosome complex subunit 4
• CSN4Arabidopsis, homolog) subunit 4
• MANOP1
• MGC10899
• MGC15160

Background

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COPS4
• Entrez:
  • 51138(Human)
• Uniprot:
  • NP_057213.(Human)