Complement Factor MASP3/MASP1 Antibody (254818) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB
• Clone: 254818
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Complement Factor MASP3/MASP1 Antibody (254818) [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor MASP3 Catalytic Domain
  Ile450-Val721
  Accession # NP_624302
• Specificity: Detect human Complement Factor MASP3 Catalytic Domain in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor MASP3/MASP1 Antibody (254818) [Alexa Fluor® 350]

• Complement Factor MASP3
• Complement factor MASP-3
• Complement-activating component of Ra-reactive factor
• CRARF1
• CRARFMAP1
• DKFZp686I01199
• EC 3.4.21
• EC 3.4.21.-
• EC 3.4.21.104
• EC 3.4.21.42
• FLJ26383
• mannan-binding lectin serine peptidase 1 (C4/C2 activating component ofRa-reactive factor)
• mannan-binding lectin serine protease 1 (C4/C2 activating component ofRa-reactive factor)
• mannan-binding lectin serine protease 1
• Mannose-binding lectin-associated serine protease 1
• Mannose-binding protein-associated serine protease
• MAp44
• MASP
• MASP1
• MASP-1
• MASP3
• MGC126283
• MGC126284
• PRSS5
• Ra-reactive factor serine protease p100
• RaRF
• Serine protease 5

Background

MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway (1). The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of microorganisms. Activation of the complement pathway via MBL is initiated by specific MASPs. Three MASPs have been identified and all have domain structures similar to those of C1r and C1s with a heavy chain (chain A) and a light chain (chain B). Chain A is composed of CUB1, EGF, CUB2, CCP1 and CCP2 while chain B corresponds to the catalytic domain found in many serine proteases. MASP1 and MASP3 are two alternatively spliced products of a single gene, which contain the same A chains but entirely different B chains. Distinct MASPs found in different MBL oligomers may have different biological activities. For example, MASP3, found together with MASP2, downregulates the C4 and C2 cleaving activity of MASP2. The protease activity of MASP3 is inhibited by serine protease inhibitors such as ecotin and AEBSF (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • NP_624302()