Coagulation Factor XI Antibody (3C7)

Product Discontinued

Coagulation Factor XI Antibody (3C7) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: F11 (NP_000119, 286 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIK
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: F11
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: It has been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Coagulation Factor XI Antibody (3C7)

• Coagulation Factor XI
• EC 3.4.21
• EC 3.4.21.27
• FXIPlasma thromboplastin antecedent
• MGC141891
• PTA

Background

Factor XI is a secreted homodimer, disulfide-linked. Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX, by selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. It is produced by platelets and megakaryocytes but is absent from other blood cells. It is activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. After activation the heavy and light chains are also linked by a disulfide bond. Factor XI belongs to the peptidase S1 family, plasma kallikrein subfamily and it contains 4 apple domains. Defects in F11 are the cause of F11 deficiency; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi Jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: F11
• Uniprot:
  • NP_000119(Human)