CHRFAM7A Antibody

Product Discontinued

CHRFAM7A Antibody Summary

• Immunogen: Peptide with sequence QKYCIYQHFQFQ corresponding to N-Terminus according to NP_647536.1.
• Epitope: N Terminus
• Specificity: This antibody is expected to recognize reported isoform NP_647536.1 only.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CHRFAM7A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:200
  • Peptide ELISA Detection limit 1:1000
• Application Notes: WB: Preliminary experiments in human brain (amygdala, hippocampus, cerebellum) lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for CHRFAM7A Antibody

• CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (familywith sequence similarity 7A, exons A-E) fusion
• CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) andFAM7A (family with sequence similarity 7A, exons A-E) fusion
• CHRNA7
• CHRNA7-DR1alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid
• CHRNA7-FAM7A fusion protein
• D-10alpha-7 nicotinic cholinergic receptor subunit
• MGC120482
• MGC120483

Background

CHRFAM7A is a gene that codes for a multi-pass membrane protein expressed in the hippocampus that is 412 amino acids long and weighs approximately 46 kDa. Current studies are being done on diseases and disorders related to this gene including neuronitis, Alzheimer's disease, juvenile myoclonic epilepsy, bipolar affective disorder, schizoaffective disorder, pharyngitis, and dementia. CHRFAM7A has been shown to have involvement in pathways such as the SIDS susceptibility pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CHRFAM7A Antibody (NBP1-36946)(1)

Publication using NBP1-36946

• Martin LF, Leonard S, Hall MH et al. Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. Am J Med Genet B Neuropsychiatr Genet 2007-07-05 [PMID: 17192894]

Bioinformatics

• Gene Symbol: CHRFAM7A
• Entrez:
  • 89832(Human)
• Uniprot:
  • NP_647536.1(Human)