Chitinase 3-like 2 Antibody (632010) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB
• Clone: 632010
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Chitinase 3-like 2 Antibody (632010) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Chitinase 3-like 2
  Tyr27-Leu390
  Accession # Q15782
• Specificity: Detects human Chitinase 3-like 2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) Chitinase 3‑like 1 or rhChitotriosidase is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Chitinase 3-like 2 Antibody (632010) [Alexa Fluor® 405]

• CHI3L2
• Chitinase 3 like 2
• Chitinase 3-like 2
• chitinase-3-like protein 2
• Chondrocyte protein 39
• YKL39
• YKL-39YKL39

Background

Chitinase 3-like 2 (CHI3L2; also chrondrocyte protein 39 and YKL-39) is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family. It is secreted by synovial fibroblasts and chondrocytes, particularly in osteoarthritis, and may contribute to extracellular matrix stability. CHI3L2 has no chitotriosidase activity, but is likely to bind some type of glycan. The human CHI3L2 precursor is 390 amino acids (aa) in length. It contains a 26 aa signal sequence and a 364 aa mature region. There are two potential alternate start sites at Met24 and Met80; a third potential isoform shows a deletion of aa 15‑24. Over aa 27‑390, human CHI3L2 shares 89% aa identity with bovine CHI3L2. No rodent CHI3L2 has been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.