CDR2 Antibody (33) [DyLight 550]

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Product Details

Summary
Reactivity Hu, Mu(-)Species Glossary
Applications WB, ELISA, IHC, IHC-P
Clone
33
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

CDR2 Antibody (33) [DyLight 550] Summary

Immunogen
N-terminal MBP-tagged full length human CDR2 [Swiss-Prot # Q01850]
Specificity
Does not cross react with mouse Cdr2 and human Cdr3.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CDR2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This CDR2 Antibody (33) is useful for Western blot, Immunoprecipitation, Immunohistochemistry on paraffin-embedded sections and ELISA. In Western blot, a single or double band can be seen around 55 kDa representing CDR2. In IHC-P, heavy nuclear staining was observed with some cytoplasmic signal in human breast cancer. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human. Does not react with mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CDR2 Antibody (33) [DyLight 550]

  • CDR62
  • cerebellar degeneration-related protein (62kD)
  • cerebellar degeneration-related protein 2
  • cerebellar degeneration-related protein 2, 62kDa
  • Major Yo paraneoplastic antigen
  • Paraneoplastic cerebellar degeneration-associated antigen
  • PCD17
  • Yo paraneoplastic antigen
  • Yo

Background

CDR2, also known as cerebellar degeneration-related protein 2 and Yo, is a tumor antigen which has been linked to a rare disorder known as Paraneoplastic cerebellar degeneration (PCD). CDR2 is expressed in a high percentage of ovary and breast tumors and has been shown as the target antigen of a naturally occurring tumor immune response in PCD patients. Additionally, a connection has been reported between CDR2 and attenuation of tumor hypoxia signaling in the papillary subtype of renal cell carcinoma (Balamurugan K et al., 2009).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for CDR2 Antibody (NBP2-10509R). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an antibody against human CDR2 to recognize thymic epithelial cells. You have several anti CDR2 antibodies. Are they against a thymic epithelial antigen or against the cerebellar degeneration-related protein 2, 62kDa?
    • Yes, the specific antibody you have inquired about is against cerebellar degeneration-related protein 2, 62 kDa. Moreover, all of our CDR2 primaries are against the same target.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP2-10509B
DyLight 405 Labeled NBP2-10509V
DyLight 488 Labeled NBP2-10509G
DyLight 650 Labeled NBP2-10509C
FITC Labeled NBP2-10509F
HRP Labeled NBP2-10509H

Additional CDR2 Products

Bioinformatics Tool for CDR2 Antibody (NBP2-10509R)

Discover related pathways, diseases and genes to CDR2 Antibody (NBP2-10509R). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for CDR2 Antibody (NBP2-10509R)

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PTMs for CDR2 Antibody (NBP2-10509R)

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Research Areas for CDR2 Antibody (NBP2-10509R)

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Blogs on CDR2.

Cerebellar Degeneration-Related Protein 2 (CDR2): Cell-Cycle Regulated Tumor Antigen
CDR2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration. CDR2 has also been shown to be a cell cycle r...  Read full blog post.

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Contact Information

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Bioinformatics

Gene Symbol CDR2