CD300b/LMIR5/CD300LB Antibody [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: Flow, CyTOF-ready
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 405

CD300b/LMIR5/CD300LB Antibody [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CD300b/LMIR5
  Ile55-His187
  Accession # NP_777552
• Specificity: Detects human CD300b/LMIR5 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human LMIR2 and recombinant mouse LMIR5 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD300b/LMIR5/CD300LB Antibody [Alexa Fluor® 405]

• CD300 antigen like family member B
• CD300 antigen-like family member B
• CD300 molecule-like family member b
• CD300b antigen
• CD300b
• CD300LB
• CLM7
• CLM-7
• CLM7IREM3CD300 molecule like family member b
• CMRF35A2
• CMRF35-A2
• CMRF35-like molecule 7
• EC 1.13.11.6
• EC 6.3.4.3
• Gm253
• Immune receptor expressed on myeloid cells 3
• IREM-3
• Leukocyte mono-Ig-like receptor 5
• LMIR5
• TREM-5
• TREM5CD300b
• Triggering receptor expressed on myeloid cells 5

Background

CD300b, also known as LMIR5, CLM7 (CMRF-35-like Molecule 7) and TREM5 (Triggering Receptor Expressed on Myeloid cells 5) belongs to a multigene family whose members are closely mapped to a region of human chromosome 17 and mouse chromosome 11. These genes encode type I membrane proteins with a single extracellular Ig-like domain and the proteins are expressed widely in leukocytes. LMIR/CD300 family proteins are immunoregulatory signaling molecules that either have cytoplasmic ITIM motifs or can interact with ITAM motif-bearing molecules through a characteristic transmembrane domain containing positively charged amino acid residues. CD300b/LMIR5 is an ITAM adaptor-associated receptor with a short cytoplasmic region. Human and mouse CD300b/LMIR5 share approximately 45% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.