Cav1.4 Antibody

Western Blot: Cav1.4 Antibody [H00000778-A01] - Detection against Immunogen (37.11 KDa) .

Product Discontinued

Cav1.4 Antibody Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: CACNA1F (NP_005174, 1878 a.a. - 1977 a.a.) partial recombinant protein with GST tag. LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMACVHAL
• Specificity: CACNA1F - calcium channel, voltage-dependent, alpha 1F subunit
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: CACNA1F
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: ICC/IF usage reported in scientific literature (PMID: 24696145).

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 24696145).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cav1.4 Antibody

• AIED
• CACNA1F
• CACNAF1
• calcium channel, voltage-dependent, L type, alpha 1F subunit
• Cav1.4
• Cav1.4alpha1
• COD4
• CORDX
• CORDX3CSNB2
• CSNB2AAland island eye disease (Forsius-Eriksson ocular albinism, ocular albinismtype 2)
• CSNBX2
• JM8
• JMC8
• OA2COD3
• voltage-dependent L-type calcium channel subunit alpha-1F
• Voltage-gated calcium channel subunit alpha Cav1.4

Background

This gene encodes a member of the alpha-1 subunit family; a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants of the gene described here have been observed but have not been thoroughly characterized. Mutations in this gene have been shown to cause incomplete X-linked congential stationary night blindness type 2 (CSNB2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cav1.4 Antibody (H00000778-A01)(1)

Publication using H00000778-A01

• Mizutani H, Yamamura H, Muramatsu M et al. Spontaneous and nicotine-induced Ca2+ oscillations mediated by Ca2+ influx in rat pinealocytes. Am J Physiol Cell Physiol. 2014-06-01 [PMID: 24696145] (ICC/IF, Rat)

Bioinformatics

• Gene Symbol: CACNA1F
• Entrez:
  • 778(Human)
• OMIM:
  • 300071(Human)
• Uniprot:
  • NP_005174(Human)