Calsyntenin-1 Antibody [DyLight 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
DyLight 594

Order Details

Calsyntenin-1 Antibody [DyLight 594] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Calsyntenin-1 isoform 2
Arg30-Thr851
Accession # AAH33902
Specificity
Detects human Calsyntenin-1 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) Calsyntenin-2 and rhCalsyntenin-3 is observed.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
CLSTN1
Purity
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Antigen Affinity-purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Calsyntenin-1 Antibody [DyLight 594]

  • alcadein alpha 1
  • Alcadein-alpha
  • ALC-ALPHA
  • alcalpha1
  • alcalpha2
  • Alzheimer-related cadherin-like protein
  • cadherin-related family member 12
  • calsyntenin 1
  • Calsyntenin1
  • Calsyntenin-1
  • CDHR12
  • CLSTN1
  • CS1
  • CSTN1
  • FLJ32258
  • KIAA0911alcadein-alpha
  • Non-classical cadherin XB31alpha
  • non-classical cadherin XB31alpha1
  • PIK3CD
  • XB31alpha

Background

CLSTN1 (calsyntenin 1) is mainly expressed in brain tissues and to a lesser degree in heart, skeletal muscle and the placenta. It accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques. The protein induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. It is involved in complex formation with APBA2 and APP, stabilizing APP metabolism and enhancing APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. It may also modulate calcium-mediated postsynaptic signals.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CLSTN1