Species: Hu
Applications: WB
Host: Sheep Polyclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
CLSTN1 (calsyntenin 1) is mainly expressed in brain tissues and to a lesser degree in heart, skeletal muscle and the placenta. It accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques. The protein induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. It is involved in complex formation with APBA2 and APP, stabilizing APP metabolism and enhancing APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. It may also modulate calcium-mediated postsynaptic signals.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
22883 |
| Alternate Names |
- alcadein alpha 1
- Alcadein-alpha
- Alc-alpha
- ALC-ALPHA
- alcalpha1
- alcalpha2
- Alzheimer-related cadherin-like protein
- cadherin-related family member 12
- calsyntenin 1
- calsyntenin-1
- CDHR12
- CS1
- CSTN1
- FLJ32258
- KIAA0911alcadein-alpha
- Non-classical cadherin XB31alpha
- non-classical cadherin XB31alpha1
- PIK3CD
- XB31alpha
|
