Calsenilin Antibody (S66-38)

Product Discontinued

Calsenilin Antibody (S66-38) Summary

• Immunogen: Fusion protein amino acids 1-256 (Full lenght) of rat Calsenilin
• Localization: Cytoplasm , Cell Membrane , Endoplasmic Reticulum , Golgi Apparatus , Nucleus
• Specificity: The product detects ~34kDa. No cross-reactivity against rat KChIps 1,2,4.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: KCNIP3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 0.1-1.0 ug/ml
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1 ug/ml

Reactivity Notes

Human, Mouse, Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 50% Glycerol
• Preservative: 0.09% Sodium Azide
• Purity: Protein G purified

Alternate Names for Calsenilin Antibody (S66-38)

• calsenilin
• calsenilin, presenilin-binding protein, EF hand transcription factor
• CSEN MGC18289
• DREAM
• DREAMA-type potassium channel modulatory protein 3
• KCHIP3 DRE-antagonist modulator
• KChIP3
• Kv channel interacting protein 3, calsenilin
• Kv channel-interacting protein 3
• potassium channel interacting protein 3

Background

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Calsenilin Antibody (NBP1-48055)(2)

Publications using NBP1-48055

• Alexander JC, McDermott CM, Tunur T, Rands V, Stelly C, Karhson D, Bowlby MR, An WF, Sweatt JD, Schrader LA. The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning. [PMID: 19223600]
• Flowerdew SE, Burgoyne RD. A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. Biochem J;418(3):529-40. 2009-03-15 [PMID: 19138172]

Bioinformatics

• Gene Symbol: KCNIP3
• Entrez:
  • 65199(Rat)
• Uniprot:
  • Q9JM47(Rat)