C1qTNF1/CTRP1 Antibody (395520) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 395520
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

C1qTNF1/CTRP1 Antibody (395520) [Alexa Fluor® 700] Summary

• Immunogen: Mouse myeloma cell line NS0-derived human CTRP1/C1qTNF1
  Arg26-Pro281
  Accession # Q9BXJ1
• Specificity: Detects human CTRP1/C1qTNF1 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for C1qTNF1/CTRP1 Antibody (395520) [Alexa Fluor® 700]

• C1q and tumor necrosis factor related protein 1
• C1qTNF1
• CTRP1
• CTRP1G protein-coupled receptor-interacting protein
• FLJ90694
• G protein coupled receptor interacting protein
• GIPcomplement C1q tumor necrosis factor-related protein 1
• ZSIG37

Background

C1qTNF1 (CTRP1) is an approximately 35 kDa member of the C1q family of secreted proteins and plays a role in energy metabolism and inflammation (1, 2). C1qTNF1 contains a collagen-like region and one C1q-like domain (3). Mature human C1qTNF1 shares 80% aa sequence identity with mouse and rat C1qTNF1. Circulating levels of C1qTNF1 are elevated in obesity, hypertension, and diabetes but can be decreased in the serum of diet-induced obese mice (4-6). C1qTNF1 expression is up-regulated in atherosclerotic plaques or adipose tissue by oxidized LDL or inflammatory cytokines (3, 7, 8). In turn, it induces the expression of inflammatory cytokines (7, 9) and the up-reglation of adhesion proteins on vascular endothelial cells (8). Systemically administered C1qTNF1, in contrast, can limit tissue damage following myocardial infarction (9). In skeletal muscle, C1qTNF1 promotes fatty acid oxidation, energy expenditure, insulin sensitivity, and glucose uptake and glycolysis (6, 10). It also induces the proliferation of immature chondrocytes (11) and aldosterone synthesis in the adrenal cortex (4). R&D Systems in-house testing indicates that C1qTNF1 binds to BAI3, consistent with the reported interactions between BAI3 and C1qL proteins (12).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.