BPNT1 Antibody

Western Blot: BPNT1 Antibody [NB100-68164] - Analysis of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

BPNT1 Antibody Summary

• Description: Novus Biologicals Goat BPNT1 Antibody (NB100-68164) is a polyclonal antibody validated for use in WB and ELISA. Anti-BPNT1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-RNYDYYASRVPESIK corresponding to C-Terminus according to NP_006076.4.
• Epitope: RNYDYYASRVPESIK
• Predicted Species: Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: BPNT1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:4000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Approx. 37 kDa band observed in human liver lysates is reported in scientific literature (PMID: 10224133).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for BPNT1 Antibody

• 3'(2'), 5'-bisphosphate nucleotidase 1,3'(2')5'-bisphosphate nucleotidase 1
• Bisphosphate 3'-nucleotidase 1
• BPntase
• EC 3.1.3
• EC 3.1.3.7
• PAP-inositol-1,4-phosphatase
• PIP

Background

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for BPNT1 Antibody (NB100-68164)(1)

Publication using NB100-68164

• Tessier PM, Lindquist S. Prion recognition elements govern nucleation, strain specificity and species barriers. Nature 2007-05-31 [PMID: 17495929]

Bioinformatics

• Gene Symbol: BPNT1
• Entrez:
  • 10380(Human)
  • 23827(Mouse)
  • 64473(Rat)
• Uniprot:
  • NP_006076.4(Human)