beta-2 Adrenergic R/ADRB2 Antibody - BSA Free

Immunocytochemistry: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Staining of untransfected HEK293 human embryonic kidney cells.

Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Human Prostate, Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunocytochemistry: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Staining of HEK293 human embryonic kidney cells transfected with ADRB2.

Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Analysis of anti-ADRB2 antibody with heart, cardiac myocytes at 5 ug/ ml.

Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Analysis of anti-ADRB2 antibody with human brain, glioblastoma.

Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Human Colon, Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

beta-2 Adrenergic R/ADRB2 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 18 amino acid peptide from C-terminus of human beta-2 Adrenergic R/ADRB2.
• Epitope: C-Terminus
• Localization: Cell Membrane
• Specificity: Human ADRB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%), Chimpanzee (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADRB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1:100 - 1:2000

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (94%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody - BSA Free

• ADRB2
• ADRB2R
• ADRBR
• adrenergic, beta-2-, receptor, surface
• B2AR
• B2ARADRB2R
• BAR
• beta-2 Adrenergic R
• beta-2 adrenergic receptor
• beta2 AdrenergicR
• beta-2 AdrenergicR
• Beta-2 adrenoceptor
• Beta-2 adrenoreceptor
• BETA2AR
• catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADRB2
• Entrez:
  • 154(Human)
• Uniprot:
  • P07550()