beta-2 Adrenergic R/ADRB2 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Staining of HEK293 human embryonic kidney cells transfected with this antibody.
Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Human Prostate, Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunocytochemistry/ Immunofluorescence: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Staining of untransfected HEK293 human embryonic kidney cells using this antibody at 5 ug/ml.
Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Analysis of anti-ADRB2 antibody with heart, cardiac myocytes at 5 ug/ ml.
Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Analysis of anti-ADRB2 antibody with human brain, glioblastoma.
Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2656] - Human Colon, Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Details

Summary
Reactivity Hu, Mk, PmSpecies Glossary
Applications WB, ICC/IF, IHC-P, ICC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

beta-2 Adrenergic R/ADRB2 Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from C-terminus of human ADRB2.
Localization
Cell Membrane
Specificity
Human ADRB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Primate (100%), Monkey (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ADRB2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:2000
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Paraffin 1:10 - 1:500
  • Immunocytochemistry 1:10 - 1:500

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (100%), Marmoset (94%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody

  • ADRB2
  • ADRB2R
  • ADRBR
  • adrenergic, beta-2-, receptor, surface
  • B2AR
  • B2ARADRB2R
  • BAR
  • beta-2 Adrenergic R
  • beta-2 adrenergic receptor
  • beta2 AdrenergicR
  • beta-2 AdrenergicR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
  • BETA2AR
  • catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ADRB2
Entrez
Uniprot