beta-2 Adrenergic R/ADRB2 Antibody (586107) [Alexa Fluor® 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
586107
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 405

beta-2 Adrenergic R/ADRB2 Antibody (586107) [Alexa Fluor® 405] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human beta ‑2 Adrenergic R/ADRB2
Accession # P07550
Specificity
Detects human beta ‑2 Adrenergic R/ADRB2 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody (586107) [Alexa Fluor® 405]

  • ADRB2
  • ADRB2R
  • ADRBR
  • adrenergic, beta-2-, receptor, surface
  • B2AR
  • B2ARADRB2R
  • BAR
  • beta-2 Adrenergic R
  • beta-2 adrenergic receptor
  • beta2 AdrenergicR
  • beta-2 AdrenergicR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
  • BETA2AR
  • catecholamine receptor

Background

Beta-2 adrenoceptor (ADRB2) is a 413 amino acids adrenergic receptor expressed in smooth muscle and metabolic tissues. Beta-adrenergic receptors belong to the seven-transmembrane domain/GPCR family of receptors and mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Activation of ADRB2 induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB100401U
Alexa Fluor 405 FAB100401V
Alexa Fluor 488 FAB100401G
Alexa Fluor 594 FAB100401T
Alexa Fluor 647 FAB100401R
Alexa Fluor 700 FAB100401N
Alexa Fluor 750 FAB100401S

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