beta-2 Adrenergic R/ADRB2 Antibody (586107) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: Flow
• Clone: 586107
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

beta-2 Adrenergic R/ADRB2 Antibody (586107) [Alexa Fluor® 488] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human beta ‑2 Adrenergic R/ADRB2
  Accession # P07550
• Specificity: Detects human beta -2 Adrenergic R/ADRB2 in direct ELISAs.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  12 months from date of receipt, 2 to 8 degreesC as supplied.
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354. This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody (586107) [Alexa Fluor® 488]

• ADRB2
• ADRB2R
• ADRBR
• adrenergic, beta-2-, receptor, surface
• B2AR
• B2ARADRB2R
• BAR
• beta-2 Adrenergic R
• beta-2 adrenergic receptor
• beta2 AdrenergicR
• beta-2 AdrenergicR
• Beta-2 adrenoceptor
• Beta-2 adrenoreceptor
• BETA2AR
• catecholamine receptor

Background

Beta-2 adrenoceptor (ADRB2) is a 413 amino acids adrenergic receptor expressed in smooth muscle and metabolic tissues. Beta-adrenergic receptors belong to the seven-transmembrane domain/GPCR family of receptors and mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Activation of ADRB2 induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for beta-2 Adrenergic R/ADRB2 Antibody (FAB100401G)(1)

Publication using FAB100401G

• Liang, J;Seghiri, M;Singh, PK;Seo, HG;Lee, JY;Jo, Y;Song, YB;Park, C;Zalicki, P;Jeong, JY;Huh, WK;Caculitan, NG;Smith, AW; The ?2-adrenergic receptor associates with CXCR4 multimers in human cancer cells Proceedings of the National Academy of Sciences of the United States of America 2024-04-02 [PMID: 38547061] (Flow Cytometry, Human, Primate - C. aethiops)

Bioinformatics

• Uniprot:
  • P07550()