Bestrophin 3 Antibody (OTI2H3)

Images

 
Western Blot: Bestrophin 3 Antibody (2H3) [NBP2-03253] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Bestrophin 3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of ...read more
Immunocytochemistry/ Immunofluorescence: Bestrophin 3 Antibody (2H3) [NBP2-03253] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY Bestrophin 3.
Flow Cytometry: Bestrophin 3 Antibody (2H3) [NBP2-03253] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-Bestrophin 3 antibody, and ...read more
Flow Cytometry: Bestrophin 3 Antibody (2H3) [NBP2-03253] - Analysis of Hela cells, using anti-Bestrophin 3 antibody, (Red), compared to a nonspecific negative control antibody (Blue).

Product Details

Summary
Reactivity Hu, MkSpecies Glossary
Applications WB, Flow, ICC/IF
Clone
OTI2H3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Bestrophin 3 Antibody (OTI2H3) Summary

Immunogen
Full length human recombinant protein of human BEST3 (NP_689652) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BEST3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:100
Theoretical MW
50.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Bestrophin 3 Antibody (OTI2H3)

  • bestrophin 3
  • bestrophin-3
  • MGC13168
  • MGC40411
  • vitelliform macular dystrophy 2-like 3
  • VMD2L3Vitelliform macular dystrophy 2-like protein 3

Background

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Discover related pathways, diseases and genes to Bestrophin 3 Antibody (NBP2-03253). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Bestrophin 3 Antibody (NBP2-03253)

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Blogs on Bestrophin 3.

"I can see clearly now": Targeting Bestrophin 1 to treat Bestrophinopathies
Encoded by the VMD2 gene on chromosome 11q13 Bestrophin 1 is the prototypic member of the RFP family of proteins which are more commonly called "bestrophins". The protein family was originally identified in Caenorhabditis elegans based on a conserved...  Read full blog post.

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Bioinformatics

Gene Symbol BEST3
Entrez