Bestrophin 3 Products

Description

VMD2L3, a bestrophin, is an anion channel. The VMD2 gene underlying vitelliform macular dystrophy and the 3 VMD2-like genes, VMD2L1, VMD2L2, and VMD2L3, encode transmembrane (TM) spanning proteins that share a homology region with a high content of aromatic residues including an invariant arginine (R), phenylalanine (F), and proline (P) motif. VMD2 and the 3 VMD2-related genes share a conserved gene structure with almost identical sizes of the 8 RFP-TM domain encoding exons and highly conserved positions of their corresponding exon-intron boundaries. Each of the 4 paralogous genes contains a unique 3-prime end of variable length without significant homology to known proteins or motifs.

Bioinformatics

Entrez	144453 Human
Product By Gene ID	144453
Alternate Names	bestrophin 3 bestrophin-3 MGC13168 MGC40411 vitelliform macular dystrophy 2-like 3 VMD2L3Vitelliform macular dystrophy 2-like protein 3

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"I can see clearly now": Targeting Bestrophin 1 to treat Bestrophinopathies Encoded by the VMD2 gene on chromosome 11q13 Bestrophin 1 is the prototypic member of the RFP family of proteins which are more commonly called "bestrophins". The protein family was originally identified in Caenorhabditis elegans based on a conserved ...    Read more.

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