ATF2 [p Ser112, p Ser94] Antibody [FITC]

Product Discontinued

ATF2 [p Ser112, p Ser94] Antibody [FITC] Summary

• Immunogen: A peptide sequence around aa.110~114 or 92~96 (D-L-S-P-L) derived from Human ATF2
• Modification: p Ser112, p Ser94
• Specificity: This antibody detects endogenous level of total ATF2 protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ATF2
• Purity: Epitope affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Epitope affinity purified

Alternate Names for ATF2 [p Ser112, p Ser94] Antibody [FITC]

• activating transcription factor 2formerly
• ATF2
• cAMP responsive element binding protein 2
• cAMP-responsive element-binding protein 2
• CREB2
• CREBP1
• CRE-BP1
• cyclic AMP-dependent transcription factor ATF-2
• HB16
• MGC111558
• mXBP
• TREB7

Background

ATF-2 (activating transcription factor-2, CRE-BP1) is a transcription factor that binds the cAMP response element (CRE) and AP-1 response element and is abundantly expressed in the brain. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2 (2). SAPK and p38 MAPK can activate, in response to cellular stress, ATF-2 by phosphorylating this protein at Thr69 and Thr71. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ATF2