AlphaB Crystallin/CRYAB Antibody (1D11C6E6)

Product Discontinued

AlphaB Crystallin/CRYAB Antibody (1D11C6E6) Summary

• Immunogen: Purified recombinant fragment of CRYAB(aa1-175) expressed in E. Coli.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: CRYAB
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:200 - 1:1000
  • Immunohistochemistry-Paraffin 1:200 - 1000
  • Western Blot 1:500 - 1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.03% Sodium Azide
• Purity: Unpurified

Alternate Names for AlphaB Crystallin/CRYAB Antibody (1D11C6E6)

• alpha B crystallin
• alpha(B)-crystallin
• AlphaB Crystallin
• alpha-crystallin B chain
• CRYA2
• CRYA2alpha crystallin B chain
• CRYAB
• crystallin, alpha B
• CTPP2
• Heat shock protein beta-5
• heat-shock 20 kD like-protein
• HSPB5
• Renal carcinoma antigen NY-REN-27
• Rosenthal fiber component

Background

Crystallin AB (CryAB) is a developmentally regulated small heat shock protein known to protect cells from stress damage. It may also play an important role in the Golgi reorganization during cell division. CryAB is known to be associated with a number of neurodegenerative pathologies such as Alzheimer disease amd multiple sclerosis. As well, it has been found to be expressed in breast tumors of patients with shorter survival, suggesting that it may be a useful marker in identifying aggressive breast cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for AlphaB Crystallin/CRYAB Antibody (NBP1-47519)(2)

Publications using NBP1-47519

• Savarese M, Vihola A, Jokela ME Et al. Out-of-Frame Mutations in ACTN2 Last Exon Cause a Dominant Distal Myopathy With Facial Weakness Neurology. Genetics 2021-10-01 [PMID: 34386585] (IF/IHC, Human)
• Wang SN, Luo S, Liu C et al. miR-491 Inhibits Osteosarcoma Lung Metastasis and Chemoresistance by Targeting aB-crystallin. Mol. Ther. 2017-09-06 [PMID: 28648665] (WB, Human)

Bioinformatics

• Gene Symbol: CRYAB
• Entrez:
  • 1410(Human)