alpha-2C Adrenergic R/ADRA2C Antibody - BSA Free

Western Blot: alpha-2C Adrenergic R/ADRA2C Antibody [NB100-93554] - Detection of Alpha 2c Adrenergic Receptor in 20 ug of human brain lysate (lane 2) with polyclonal antibody NB100-93554 at a dilution of 1:1000 followed by AP-conjugated secondary antibody at 1:5000 dilution. Lane 1 represents the MW markers.

Immunohistochemistry: alpha-2C Adrenergic R/ADRA2C Antibody [NB100-93554] - Staining of Alpha 2c Adrenergic Receptor in rat's ventral spinal cord. NB100-93554 was employed at a dilution of 1:100-1:300 and detection was carried out using HRP-AEC staining reagents (red color) followed by counterstaining with hematoxylin.

Product Discontinued

alpha-2C Adrenergic R/ADRA2C Antibody - BSA Free Summary

• Immunogen: Synthetic peptide comprising internal residues of the human Alpha 2c protein. Reacts with rat and mouse Alpha 2c.
• Specificity: Alpha2c protein
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADRA2C
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:300
  • Western Blot 1:500-1:1000
• Application Notes: This antibody is useful for Western blot 1:500-1:1000, and immunohistochemistry 1:100-1:300. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 49.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  alpha-2C Adrenergic R/ADRA2C Overexpression Lysate

Reactivity Notes

This antibody is reactive against Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for alpha-2C Adrenergic R/ADRA2C Antibody - BSA Free

• a-2C AdrenergicR
• ADRA2C
• ADRA2L2
• ADRA2L2alpha-2CAR
• ADRA2RL2
• ADRARL2
• adrenergic, alpha-2C-, receptor
• Alpha-2 adrenergic receptor subtype C4
• alpha2-AR-C4
• alpha-2C Adrenergic R
• alpha-2C adrenergic receptor
• alpha2C AdrenergicR
• Alpha-2C adrenoceptor
• Alpha-2C adrenoreceptor
• alpha-2C-adrenergic receptor
• ALPHA2CAR
• Alpha-2CAR

Background

The alpha-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. There are 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha2C is required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for alpha-2C Adrenergic R/ADRA2C Antibody (NB100-93554)(2)

Publications using NB100-93554

• Thapa D, Valente JS, Barrett B Et al. Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing eLife 2021-11-02 [PMID: 34726597] (WB, Mouse)
• Mei B, Li J, Zuo Z. Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central ?2A adrenoceptor Brain, Behavior, and Immunity 2021-01-01 [PMID: 33039659]

Bioinformatics

• Gene Symbol: ADRA2C
• Entrez:
  • 152(Human)
  • 11553(Mouse)
  • 24175(Rat)
• Uniprot:
  • NP_000674()