alpha-2C Adrenergic R/ADRA2C Antibody (S330A-51)

Product Discontinued

alpha-2C Adrenergic R/ADRA2C Antibody (S330A-51) Summary

• Immunogen: Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor
• Localization: Cell Membrane
• Specificity: Detects 50kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: ADRA2C
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:500
  • Western Blot 1:100 - 1:2000
• Application Notes: Use in FLOW reported in scientific literature (PMID: 30537999).

Packaging, Storage & Formulations

• Storage: Store at -20C.
• Buffer: PBS pH7.4, 50% glycerol
• Preservative: 0.09% Sodium Azide
• Purity: Protein G purified

Alternate Names for alpha-2C Adrenergic R/ADRA2C Antibody (S330A-51)

• a-2C AdrenergicR
• ADRA2C
• ADRA2L2
• ADRA2L2alpha-2CAR
• ADRA2RL2
• ADRARL2
• adrenergic, alpha-2C-, receptor
• Alpha-2 adrenergic receptor subtype C4
• alpha2-AR-C4
• alpha-2C Adrenergic R
• alpha-2C adrenergic receptor
• alpha2C AdrenergicR
• Alpha-2C adrenoceptor
• Alpha-2C adrenoreceptor
• alpha-2C-adrenergic receptor
• ALPHA2CAR
• Alpha-2CAR

Background

The alpha-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. There are 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha2C is required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for alpha-2C Adrenergic R/ADRA2C Antibody (NBP2-59377)(1)

Publication using NBP2-59377

• Su X, Fan Y, Yang L et al. Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery J Transl Med 2018-12-11 [PMID: 30537999] (FLOW, Human)

Bioinformatics

• Gene Symbol: ADRA2C