alpha-1B Adrenergic R/ADRA1B Antibody

Western Blot: alpha-1B Adrenergic R/ADRA1B Antibody [NBP2-26181] - Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Western Blot: alpha-1B Adrenergic R/ADRA1B Antibody [NBP2-26181] - Pig Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu, Mu, Rt, Po, Bv, Ca
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

alpha-1B Adrenergic R/ADRA1B Antibody Summary

• Immunogen: Peptide with sequence C-SSTKAKGHNPRSS corresponding to internal region according to NP_000670.1.
• Predicted Species: Canine (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ADRA1B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
  • Western Blot 0.1 - 0.3 ug/ml
• Application Notes: WB: Approx. 55-60 kDa band observed in human, mouse, rat and porcine heart lysates (calculated MW of 56.8 kDa band according to NP_000670.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for alpha-1B Adrenergic R/ADRA1B Antibody

• a-1B AdrenergicR
• ADRA1
• ADRA1B
• adrenergic, alpha-1B-, receptor
• alpha-1B Adrenergic R
• alpha-1B adrenergic receptor
• alpha1B AdrenergicR
• Alpha-1B adrenoceptor
• Alpha-1B adrenoreceptor
• alpha-1B-adrenergic receptor
• ALPHA1BAR

Background

The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation. The alpha-1b adrenoceptor has been documented in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen. ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for alpha-1B Adrenergic R/ADRA1B Antibody (NBP2-26181)(1)

Publication using NBP2-26181

• Powe DG, Voss MJ, Habashy HO et al. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast Cancer Res Treat 2011-11-01 [PMID: 21298476]

Bioinformatics

• Gene Symbol: ADRA1B
• Entrez:
  • 147(Human)
  • 11548(Mouse)
  • 24173(Rat)