Actin Alpha 1 Cardiac Muscle Antibody (959615) [Alexa Fluor® 647]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: 959615
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Actin Alpha 1 Cardiac Muscle Antibody (959615) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human α-Cardiac Actin
  Asp3-Phe377
  Accession # P68032
• Specificity: Detects human alpha -Cardiac Actin in direct ELISAs. Detects human,mouse, and rat alpha -Cardiac Actin in Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Actin Alpha 1 Cardiac Muscle Antibody (959615) [Alexa Fluor® 647]

• ACTC
• ACTC1
• actin, alpha, cardiac muscle 1
• alpha-Cardiac Actin
• ASD5
• Cardiac alpha-Actin
• CMD1R
• CMH11
• LVNC4

Background

Actin, alpha cardiac muscle 1 (ACTC1) is a 377 aa cytoskeletal filament in cardiac muscle which interacts with the 50-KDa domain of the myosin motor domain in cardiac muscle contraction. Actin is highly conserved across species, and differs from skeletal muscle actin (ACTA1) by only four amino acids. Mutations in the ACTC1 gene are linked to familial hypertrophy cardiomyopathy, atrial septal defects, arrhythmia, and chronic inflammatory cardiomyopathy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.