5-HT1B Antibody

Product Discontinued

5-HT1B Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT1B Receptor.
• Localization: Cell Membrane
• Specificity: Human 5HT1B Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%), Equine (94%), Monkey (94%), Feline (100%), Opossum (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HTR1B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10-1:500
• Control:

  5-HT1B Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (100%), Gibbon (100%), Marmoset (100%), Elephant (100%), Panda (100%), Chicken (88%), Lizard (88%), Xenopus (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for 5-HT1B Antibody

• 5HT1B
• 5-HT1B
• 5-HT1B5-HT-1B
• 5HT1DB
• 5-HT1DB
• 5-hydroxytryptamine (serotonin) receptor 1B
• HTR1B
• HTR1D2
• HTR1D2,5-hydroxytryptamine receptor 1B
• HTR1DB
• S12
• S125-HT-1D-beta
• Serotonin 1D beta receptor
• Serotonin receptor 1B

Background

5-HT1B (5-HT1D beta), a Serotonin Receptor, inhibits neurotransmitter release from neuronal terminals. Knockout mutant mice lacking this receptor exhibit decreased anxiety, increased aggression, and augmented alcohol and cocaine consumption compared to controls. 5-HT1B receptors have been found to control areas of the human brain involved in migraine pain, bipolar disorder, and obsessive compulsive disorder. The 5-HT1B receptor has been reported to be expressed in a variety of neurons predominantly in the central nervous system. It has been suggested that Human 5-HT1B receptors are located somatodendritically on GABAergic and peptidergic caudate-putamen neurons which project to the substantia nigra and globus pallidus, where these receptors are presynaptic. 5-HT1B expression has also been seen in heart, blood vessels, and eye.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for 5-HT1B Antibody (NLS598)(1)

Publication using NLS598

• Guilluy, C, Rolli-Derkinderen, M, Tharaux, P-L, Melino, G, Pacaud, P, Loir, G. Transglutaminase-dependent RhoA Activation Depletion by Serotonin in Vascular Smooth Muscle Cells. 282, 2918-2928. 2007-01-01 [PMID: 17142836]

Bioinformatics

• Gene Symbol: HTR1B
• Entrez:
  • 3351(Human)