17 beta-HSD14/HSD17B14 Antibody (736043) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC
• Clone: 736043
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

17 beta-HSD14/HSD17B14 Antibody (736043) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human 17 beta ‑HSD14/HSD17B14
  Ala2-Ser270
  Accession # Q9BPX1
• Specificity: Detects human 17 beta ‑HSD14/HSD17B14 in direct ELISAs.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 17 beta-HSD14/HSD17B14 Antibody (736043) [Alexa Fluor® 647]

• 17 betaHSD14
• 17 beta-HSD14
• dehydrogenase/reductase (SDR family) member 10
• Dehydrogenase/reductase SDR family member 10
• DHRS10
• DHRS1017-beta-hydroxysteroid dehydrogenase 14
• EC 1.1.1.-
• HSD17B14
• hydroxysteroid (17-beta) dehydrogenase 14,17-beta-hydroxysteroid dehydrogenase DHRS10
• retinal short-chain dehydrogenase/reductase 3
• Retinal short-chain dehydrogenase/reductase retSDR3
• retSDR3
• RETSDR3,17-beta-HSD 14
• SDR3
• SDR47C1
• short chain dehydrogenase/reductase family 47C, member 1

Background

HSD-17b14 (hydroxysteroid (17-beta) dehydrogenase type14), also called 17bHSD14 or DHRS10, is a cytoplasmic 17beta-hydroxysteroid dehydrogenase that is a member of the SDR (short-chain dehydrogenase/reductase) family. It is a 270 amino acid, approximately 30 kDa protein with mRNA highly expressed in brain, placenta, liver and kidney. It converts estradiol to estrone, thus inactivating it, and is thought to regulate activity of estrogens and possibly dihydroepiandrosterone (DHEA) in the placenta and central nervous system. Human HSD-17b14 shares 80.5% amino acid sequence identity with mouse and rat HSD-17b14.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q9BPX1(Human)