MAP2 Products

Antibodies
MAP2 Antibody
MAP2 Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, KD
Host: Chicken Polyclonal
ELISA Kits
Human MAP2 ELISA Kit (Chemilu ...
Human MAP2 ELISA Kit (Chemilumines...
NBP2-80251
Species: Hu
Applications: ELISA
Human MAP2 ELISA Kit (Colorim ...
Human MAP2 ELISA Kit (Colorimetric)
NBP2-80250
Species: Hu
Applications: ELISA
Lysates
MAP2 Overexpression Lysate
MAP2 Overexpression Lysate
NBP2-06122
Species: Hu
Applications: WB
MAP2 Overexpression Lysate
MAP2 Overexpression Lysate
NBP2-08120
Species: Hu
Proteins
Recombinant Human MAP2 GST (N ...
Recombinant Human MAP2 GST (N-Term...
H00004133-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
MAP2 Recombinant Protein Anti ...
MAP2 Recombinant Protein Antigen
NBP2-61417PEP
Species: Hu
Applications: AC

Description

Microtubule-associated protein 2 also known as MAP2 (theoretical molecular weight 199 kDa) belongs to the MAP2/Tau family which in addition to the two neuronal forms MAP2 and Tau also includes MAP4 (1). For MAP2, four different isoforms have been identified which are produced through alternative splicing including MAP2a, MAP2b, MAP2c and MAP2d (1). MAP2 isoforms contain multiple microtubule-binding domains located near the carboxy terminal, a variably sized amino-terminal projection domain, and a conserved protein kinase A binding domain. MAP2c and MAP2d isoforms have a shorter amino-terminal projection domain, lower molecular weight and are identifiable at ~70 kDa in SDS-PAGE analysis (2,3). MAP2's carboxy terminal domain supports interactions with microtubules, actin, and intermediate filaments (2).

MAP2 isoforms are developmentally regulated and differentially expressed in neurons and some glia. MAP2c is predominantly expressed in the developing brain while the other isoforms are expressed in the adult brain. The distribution of MAP2 isoforms also varies, with MAP2a and MAP2b predominantly localized to dendrites, while MAP2c is also found in axons. Lastly, the expression of MAP2d is not limited to neurons and may be found in glia, specifically oligodendrocytes (1, 2). MAP2 isoforms associate with microtubules and mediate their interaction with actin filaments thereby playing a critical role in organizing the microtubule-actin network. In neurons, MAP2 isoforms are implicated in different processes including neurite initiation, elongation and stabilization as well as axon and dendrite formation (2). Knockout of MAP expression in animal models results in a variety of functional and structural brain defects according to the isoform affected (e.g., reduced LTP and LTD, reduced myelination, absence of corpus collosum, motor system malfunction, abnormal hippocampal dendritic morphology, abnormal synaptic plasticity) (4).

References

1. Dehmelt, L., & Halpain, S. (2005). The MAP2/Tau family of microtubule-associated proteins. Genome Biology. https://doi.org/10.1186/gb-2004-6-1-204

2. Mohan, R., & John, A. (2015). Microtubule-associated proteins as direct crosslinkers of actin filaments and microtubules. IUBMB Life. https://doi.org/10.1002/iub.1384

3. Shafit-Zagardo, B., & Kalcheva, N. (1998). Making sense of the multiple MAP-2 transcripts and their role in the neuron. Molecular Neurobiology. https://doi.org/10.1007/BF02740642

4. Tortosa, E., Kapitein, L. C., & Hoogenraad, C. C. (2016). Microtubule organization and microtubule-associated proteins (MAPs). In Dendrites: Development and Disease. https://doi.org/10.1007/978-4-431-56050-0_3

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 4133
Alternate Names
  • MTAP2
  • Microtubule Associated Protein 2
  • MAP2C
  • MAP2B
  • DKFZp686I2148
  • MAP2A
  • MAP-2
  • microtubule-associated protein 2

Research Areas for MAP2

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Cytoskeleton Markers
MAP Kinase Signaling
Neuroscience
Phospho-Specific
Stem Cell Markers

Bioinformatics Tool for MAP2

Discover related pathways, diseases and genes to MAP2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MAP2 Blog Posts

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Beta Tubulin III and neurogenesis
Beta tubulin III, also known as Tuj-1, is a class III member of the beta tubulin protein family. Beta tubulins are one of two structural components that form our microtubule network. While general tubulins play a role in a wide range of cellular pr...    Read more.
Synapsin I: Implicated in synaptic activity across a diverse range of studies
Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...    Read more.
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