Laminin Products

Antibodies
ELISA Kits
Mouse Laminin ELISA Kit (Colo ...
Mouse Laminin ELISA Kit (Colorimet...
KA0380
Species: Mu
Applications: ELISA, Quantification
Rat Laminin ELISA Kit (Colori ...
Rat Laminin ELISA Kit (Colorimetric)
KA0379
Species: Rt
Applications: ELISA, Quantification
Human Laminin ELISA Kit (Colo ...
Human Laminin ELISA Kit (Colorimet...
KA1999
Species: Hu
Applications: ELISA, Quantification
Proteins
Laminin Recombinant Protein A ...
Laminin Recombinant Protein Antigen
NBP2-42384PEP
Species: Hu
Applications: AC

Description

Laminin, the most abundant structural and biologically active component in basement membranes, is a complex extracellular glycoprotein with high molecular weight (900 kDa). Laminin is composed of a laminin alpha (400 kDa), beta (215 kDa) and gamma chain (205 kDa), whose multidomain proteins are encoded by distinct genes (LAMA, LAMB, LAMC respectively) and have several isoforms of each chain. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, reflecting diverse functions in vivo. Laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Laminins are an important and biologically active part of the basal lamina, influencing cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis, where anti-laminin antibodies can be widely used to label blood vessels and basement membranes (1). Significant quantities of laminin are found in basement membranes, the thin extracellular matrices that surround epithelial tissue, nerve, fat cells and smooth, striated and cardiac muscle. Excessive serum laminin levels have been associated with fibrosis, cirrhosis and hepatitis, serious and frequent complications of chronic active liver disease characterized by excessive deposition of various normal components of connective tissue in liver (2). Epithelial mesenchymal transition (EMT) biomarkers include fibronectin, laminin, N-cadherin, and Slug (3).

References

1. Yang, M. Y., Chiao, M. T., Lee, H. T., Chen, C. M., Yang, Y. C., Shen, C. C., & Ma, H. I. (2015). An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior. J Biomed Mater Res B Appl Biomater, 103(3), 618-628. doi:10.1002/jbm.b.33214

2. Mak, K. M., & Mei, R. (2017). Basement Membrane Type IV Collagen and Laminin: An Overview of Their Biology and Value as Fibrosis Biomarkers of Liver Disease. Anat Rec (Hoboken), 300(8), 1371-1390. doi:10.1002/ar.23567

3. Choi, S., Yu, J., Park, A., Dubon, M. J., Do, J., Kim, Y.,... Park, K. S. (2019). BMP-4 enhances epithelial mesenchymal transition and cancer stem cell properties of breast cancer cells via Notch signaling. Sci Rep, 9(1), 11724. doi:10.1038/s41598-019-48190-5

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Mouse
Product By Gene ID 284217
Alternate Names
  • PTBHS
  • Laminin-1 subunit alpha
  • LAMA
  • laminin subunit alpha-1
  • Laminin-3 subunit alpha
  • S-laminin subunit alpha
  • Laminin A chain
  • S-LAM alpha
  • laminin, alpha 1

Research Areas for Laminin

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix
Neuroscience
Signal Transduction
Tumor Suppressors

PTMs for Laminin

Learn more about PTMs related to Laminin.

Phosphorylation
Cleavage
Methylation

Bioinformatics Tool for Laminin

Discover related pathways, diseases and genes to Laminin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Laminin Blog Posts

Check out the latest blog posts on Laminin.
Alpha-smooth muscle actin and the modulation of endothelial and epithelial cell biology
Actin is essential for a wide range of cell functions, ranging from cell division and chromatin remodeling to vesicle trafficking and maintenance of cellular structure. In fact, mislocalization of actin to cell junctions during development leads t...    Read more.
Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...    Read more.
Could Laminin be Used to Treat Duchenne Muscular Dystrophy?
Duchenne muscular dystrophy (DMD) is a severe muscle wasting condition, causing disability and early death. There is currently no cure or adequate treatment for DMD, but pioneering research indicates that injection of a laminin protein may prevent (or...    Read more.
Using the Laminin Antibody in Angiogenesis Research
Laminin is one of a large number of proteins expressed on the basal laminar of the ECM (extracellular matrix). The laminin antibody database covers several proteins, which interact with integrins and other receptor proteins to support cellular differe...    Read more.
Read more Laminin related blogs.