N-Cadherin Products

N-Cadherin Antibody [Unconjug ...
N-Cadherin Antibody [Unconjugated]
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, IHC, CyTOF-ready, ICC/IF
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
N-Cadherin Antibody (5D5)
N-Cadherin Antibody (5D5)
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Human N-Cadherin DuoSet ELISA ...
Human N-Cadherin DuoSet ELISA, 5 P...
Species: Hu
Applications: ELISA
Rat N-Cadherin ELISA Kit (Col ...
Rat N-Cadherin ELISA Kit (Colorime...
Species: Rt
Applications: ELISA
Mouse N-Cadherin ELISA Kit (C ...
Mouse N-Cadherin ELISA Kit (Colori...
Species: Mu
Applications: ELISA
N-Cadherin Overexpression Lys ...
N-Cadherin Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human N-Cadherin ...
Recombinant Human N-Cadherin Fc Ch...
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse N-Cadherin ...
Recombinant Mouse N-Cadherin Fc Ch...
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human N-Cadherin ...
Recombinant Human N-Cadherin His P...
Species: Hu
Applications: PAGE


N-Cadherin, also referred to as Neural Cadherin (NCAD) or Cadherin-2 (CHD2), is a 130 kDa protein that is a member of the calcium-dependent adhesion molecule family of classical (type I) cadherins (1-4). Under the CDH2 gene, human N-cadherin is synthesized as a 906 amino acid protein with a theoretical molecular weight of 99.8 kDa (5). The N-cadherin protein structure is similar to other classical type I cadherins including epithelial (E-) cadherin and placental (P-) cadherin (1,2). N-cadherin consists of a 25 amino acid (aa) N-terminal signal peptide and 134 aa pro-peptide, a 565 aa extracellular domain (ECD) with five cadherin repeats, a 21 aa transmembrane segment, and a 161 aa cytoplasmic domain (1-3,5). The ECD of N-cadherin monomers is responsible for homotypic binding through either cis or trans adhesion (2,3).

N-cadherin is expressed on multiple cell types but is most highly expressed by mesenchymal cells and neural tissue (2). Functionally, N-cadherin has a number of roles including maintaining structural integrity and adhesion, cell signaling, and formation of neuronal synapses and the vascular wall (2). The cytoplasmic tail interacts with beta-catenin which then binds with alpha-catenin, forming the cadherin-catenin adhesion complex, an important component of adhesions junctions (1-3). Given its role in adhesion, N-cadherin serves as an indicator of epithelial-to-mesenchymal transition (EMT) (1-4). The loss of E-cadherin during EMT corresponds with an increase in N-cadherin expression (1-4). This "cadherin-switch" is associated with increased migratory and invasive behavior observed in tumor progress (1-4). Proteases including activity of a disintegrin and metalloprotease 10 (ADAM10), matrix metalloproteinases (MMPs), caspase 3, presenilin, and calpain can cleave N-cadherin as a mechanism for regulating Wnt/beta-catenin signaling and inducing oncogenic signals (3,4). In addition to its expression in solid tumors, N-cadherin has been indicated in hematological disorders such as leukemia and multiple myeloma (1). N-cadherin antagonists are currently being studied as potential therapeutics for a variety of cancer studies (1-2).


1. Mrozik, K. M., Blaschuk, O. W., Cheong, C. M., Zannettino, A., & Vandyke, K. (2018). N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer. BMC Cancer. https://doi.org/10.1186/s12885-018-4845-0

2. Loh, C. Y., Chai, J. Y., Tang, T. F., Wong, W. F., Sethi, G., Shanmugam, M. K., Chong, P. P., & Looi, C. Y. (2019). The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells. https://doi.org/10.3390/cells8101118

3. Derycke, L. D., & Bracke, M. E. (2004). N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. The International Journal of Developmental Biology. https://doi.org/10.1387/ijdb.041793ld

4. Yu, W., Yang, L., Li, T., & Zhang, Y. (2019). Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target. Frontiers in Oncology. https://doi.org/10.3389/fonc.2019.00989

5. Unitprot (P1903)


Uniprot Human
Product By Gene ID 1000
Alternate Names
  • ARVD14
  • cadherin 2, type 1, N-cadherin (neuronal)
  • cadherin-2
  • calcium-dependent adhesion protein, neuronal
  • CD325 antigen
  • CD325
  • CDH2
  • CDHN
  • CDw325
  • NCAD
  • N-cadherin 1
  • N-cadherin
  • Neural cadherin
  • neural-cadherin

Research Areas for N-Cadherin

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Cellular Markers
Extracellular Matrix
Plasma Membrane Markers
Signal Transduction

Bioinformatics Tool for N-Cadherin

Discover related pathways, diseases and genes to N-Cadherin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

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Epithelial-Mesenchymal Transition (EMT) Markers
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Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling
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