N-Cadherin Products

Antibodies
N-Cadherin Antibody [Unconjug ...
N-Cadherin Antibody [Unconjugated]
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, IHC, CyTOF-ready, ICC/IF
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
N-Cadherin Antibody (5D5)
N-Cadherin Antibody (5D5)
NBP1-51612
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
N-Cadherin Knockout 293T Cell ...
N-Cadherin Knockout 293T Cell Lysate
NBP2-66344
Species: Hu
Applications: WB
N-Cadherin Overexpression Lys ...
N-Cadherin Overexpression Lysate (...
NBL1-09030
Species: Hu
Applications: WB
Proteins
Recombinant Human N-Cadherin ...
Recombinant Human N-Cadherin Fc Ch...
1388-NC
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse N-Cadherin ...
Recombinant Mouse N-Cadherin Fc Ch...
6626-NC
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human N-Cadherin ...
Recombinant Human N-Cadherin Protein
NBP2-59927
Species: Hu
Applications: PAGE
RNAi
N-Cadherin RNAi
N-Cadherin RNAi
H00001000-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Cadherins are members of a multigene family of single chain glycoprotein receptors mediating Ca++-dependent cell-cell adhesion.1,2,3 The N-terminal part of these molecules is exposed on the external cell surface and contains the putative homophilic binding sites. This is followed by a typical single transmembrane sequence and usually, a cytoplasmic C-terminal tail4 which mediates interaction with the microfilament system through molecules such as catenins, plakoglobin, vinculin, and a-actinin. Cadherins which are primarily located in areas of cell-cell contacts, are involved in selective cell sorting and in the mechanical cytoplasmic response. They are implicated in morphogenetic processes, intercellular signalling and tumor invasiveness and metastasis. Multiple cadherins were characterized from diverse species and tissues including E-Cadherin, N-Cadherin (A-CAM), P-Cadherin, V-Cadherin, R-Cadherin and T-Cadherin. Specific antibodies against a highly conserved sequence from the cytoplasmic C-terminal of N-Cadherin have been prepared.5,6

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 1000
Alternate Names
  • cadherin 2, N-cadherin (neuronal)
  • CD325 antigen
  • CDw325
  • N-cadherin
  • Neural cadherin
  • neural-cadherin
  • CD325
  • NCADN-cadherin 1
  • CDHNcalcium-dependent adhesion protein, neuronal
  • cadherin-2
  • cadherin 2, type 1, N-cadherin (neuronal)

Research Areas for N-Cadherin

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Cellular Markers
Extracellular Matrix
Phospho-Specific
Plasma Membrane Markers
Signal Transduction

Bioinformatics Tool for N-Cadherin

Discover related pathways, diseases and genes to N-Cadherin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related N-Cadherin Blog Posts

Check out the latest blog posts on N-Cadherin.
Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling
By Jamshed Arslan Pharm.D. Gastric carcinoma is the second leading cause of cancer-related deaths worldwide. One of the key features of gastric carcinoma is acidosis, which promotes growth and metastasis of gastric...    Read more.
Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...    Read more.
CD63: is it pro-metastatic or anti-metastatic?
CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,...    Read more.
MMP24 (Matrix metalloproteinase-24, matrix metalloproteinase-25, MT5-MMP)
MMP24 is an extracellular matrix (ECM) degradative peptidase enzyme that is a member of the large family of matrix metalloproteinases (MMP). Each MMP has a different substrate specificity, and the aberrant or derailed expression of these is strongly c...    Read more.
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