alpha Tubulin Products

Antibodies
Lysates
alpha Tubulin Overexpression ...
alpha Tubulin Overexpression Lysate
NBL1-17427
Species: Hu
Applications: WB
Proteins
Recombinant Human alpha Tubul ...
Recombinant Human alpha Tubulin GS...
H00007846-P01
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human alpha Tubul ...
Recombinant Human alpha Tubulin GS...
H00007846-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
alpha Tubulin Recombinant Pro ...
alpha Tubulin Recombinant Protein ...
NBP2-54687PEP
Species: Hu
Applications: AC

Description

Tubulin is the major building block of microtubules. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton. The tubulin superfamily is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22 nm diameter with a theoretical molecular weight of 50 kDa.

Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation which is characteristic for microtubules in neuronal cells and the mitotic spindle.

Like GAPDH and beta-actin, alpha/beta tubulin is often used as a loading control in immunoblot applications (1). Alpha/beta tubulin is also good for counterstaining microtubules in immunofluorescence (2).

References

1. Hannen, R., Selmansberger, M., Hauswald, M., Pagenstecher, A., Nist, A., Stiewe, T.,... Bartsch, J. W. (2019). Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor. Cancers (Basel), 11(7). doi:10.3390/cancers11070921

2. Nel, M., Joubert, A. M., Dohle, W., Potter, B. V., & Theron, A. E. (2018). Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines. Drug Des Devel Ther, 12, 1881-1904. doi:10.2147/dddt.S152718



Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 7846
Alternate Names
  • TUBA3
  • hum-a-tub1
  • Tubulin B-alpha-1
  • tubulin, alpha, brain-specific
  • Tubulin alpha-3 chain
  • tubulin, alpha 3
  • Alpha-tubulin 3
  • tubulin alpha-1A chain
  • FLJ25113
  • hum-a-tub2
  • B-ALPHA-1
  • LIS3
  • tubulin, alpha 1a

Research Areas for alpha Tubulin

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cell Cycle and Replication
Cytoskeleton Markers
Loading Controls
Neuroscience
Phospho-Specific
Stem Cell Markers

PTMs for alpha Tubulin

Learn more about PTMs related to alpha Tubulin.

Ribosylation
Cleavage
Acetylation
Glutamylation

Bioinformatics Tool for alpha Tubulin

Discover related pathways, diseases and genes to alpha Tubulin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

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Alpha Tubulin: A Fundamental Cytoskeleton Protein with Many Roles
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