AIF-1/Iba1 Products

Antibodies
AIF-1/Iba1 Antibody
AIF-1/Iba1 Antibody
Species: Hu, Mu, Rt, Ca, Fe, Po, Bv, RM
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, PEP-ELISA, Dual ISH-IHC, IHC-FrFl, IHC-WhMt, KO
Host: Goat Polyclonal
AIF-1/Iba1 Antibody
AIF-1/Iba1 Antibody
Species: Hu, Mu, Rt, Pm, Po, RM
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
AIF-1/Iba1 Antibody
AIF-1/Iba1 Antibody
Species: Hu, Mu, Rt, Po, RM
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
ELISA Kits
Human AIF-1/Iba1 ELISA Kit (C ...
Human AIF-1/Iba1 ELISA Kit (Chemil...
NBP2-66674
Species: Hu
Applications: ELISA
Rat AIF-1/Iba1 ELISA Kit (Col ...
Rat AIF-1/Iba1 ELISA Kit (Colorime...
NBP2-66675
Species: Rt
Applications: ELISA
Lysates
AIF-1/Iba1 Overexpression Lys ...
AIF-1/Iba1 Overexpression Lysate
NBL1-07408
Species: Hu
Applications: WB
Proteins
Recombinant Human AIF-1/Iba1 ...
Recombinant Human AIF-1/Iba1 Protein
NBP1-51074
Species: Hu
Applications: PAGE
AIF-1/Iba1 Recombinant Protei ...
AIF-1/Iba1 Recombinant Protein Ant...
NBP2-14276PEP
Species: Hu
Applications: AC
AIF-1/Iba1 Recombinant Protei ...
AIF-1/Iba1 Recombinant Protein Ant...
NBP2-68800PEP
Species: Hu
Applications: AC

Description

Allograft inflammatory factor (AIF-1) or ionized calcium-binding adapter molecule 1 (Iba1) is a cytosolic actin binding protein containing a calcium binding domain (EF-hand) and inducible by cytokines and INF-gamma (1). AIF-1 (theoretical molecular weight 17kDa) was first cloned from rat and human cardiac allografts and macrophage cell lines. In cardiac allografts, expression of AIF-1 was specifically associated with infiltrated mononuclear cells (2, 3). AIF-1 is constitutively expressed and inducible in macrophages and microglia. Iba1, microglia response factor (MRF-1) and daintain were independently cloned and identified in rat and human tissues and share complete sequence identity with AIF-1. Additionally, several AIF-1 splice variants have been identified including IRT-1, BART-1, G1 and Hara-1 (2).

Several cellular functions have been associated with AIF-1/Iba1 expression including cell growth, cell migration, actin bundling, membrane ruffling, and phagocytic activity (2, 4). Iba1 induces Rac signaling through a PLC-gamma dependent pathway (1). Rac, a member of the Rho family of small GTPases, localizes with Iba1 and F-actin in membrane ruffles and phagocytic cups and plays a role in microglia activation. AIF-1/Iba1 induction in macrophages and microglia occur in association with immunological inflammatory processes in various disease states including endometriosis, cerebral infarction and rheumatoid arthritis (5). Immunodetection of Iba1 through flow cytometry, immunohistochemical or immunocytochemical applications is commonly used for identification and analysis of microglia.

References

1. Imai, Y., & Kohsaka, S. (2002). Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1. GLIA. https://doi.org/10.1002/glia.10149

2. Deininger, M. H., Meyermann, R., & Schluesener, H. J. (2002). The allograft inflammatory factor-1 family of proteins. FEBS Letters. https://doi.org/10.1016/S0014-5793(02)02430-4

3. Utans, U., Quist, W. C., Mcmanus, B. M., Wilson, J. E., Arceci, R. J., Wallace, A. F., & Russell, M. E. (1996). Allograft inflammatory factor-1: A cytokine-responsive macrophage molecule expressed in transplanted human hearts. Transplantation. https://doi.org/10.1097/00007890-199605150-00018

4. Franco-Bocanegra, McAuley, Nicoll, & Boche. (2019). Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer's Disease. Cells. https://doi.org/10.3390/cells8060639

5. Kimura, M., Kawahito, Y., Obayashi, H., Ohta, M., Hara, H., Adachi, T.,... Yoshikawa, T. (2007). A Critical Role for Allograft Inflammatory Factor-1 in the Pathogenesis of Rheumatoid Arthritis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.5.3316

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 199
Alternate Names
  • AIF-1
  • IRT1
  • IBA1
  • IbaI
  • G1
  • Ionized calcium-binding adapter molecule 1
  • interferon gamma responsive transcript
  • IRT-1
  • Protein G1
  • allograft inflammatory factor 1

Research Areas for AIF-1/Iba1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication
Chromatin Research
Mitochondrial Markers
Tumor Suppressors

Bioinformatics Tool for AIF-1/Iba1

Discover related pathways, diseases and genes to AIF-1/Iba1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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