AHR Products

Description

The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.

Bioinformatics

Entrez	196 Human 11622 Mouse 25690 Rat
Uniprot	P35869 Human
Product By Gene ID	196
Alternate Names	Ah receptor AHR AH-receptor aryl hydrocarbon receptor BHLHE76 bHLHe76aromatic hydrocarbon receptor Class E basic helix-loop-helix protein 76

Research Areas for AHR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Hypoxia
Innate Immunity
Transcription Factors and Regulators

Related AHR Blog Posts

Check out the latest blog posts on AHR.

AHR - A transcription factor regulating immunity and tumorigenesis The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that controls the expression of a diverse set of genes. In the absence of ligand, AHR is retained in the cytoplasm. Upon ligand binding AHR translocates to the nucleus w...    Read more.

Aryl Hydrocarbon Signaling: AIP, AhR, ARNT, BMAL1 and more... AH receptor-interacting protein (AIP) is a 37 kD immunophilin-like factor found in a variety of tissues with expression levels ranging from high (spleen, thymus, pituitary heart, placenta and skeletal muscle) to low (liver, kidney and lung). It mediat...    Read more.

Read more AHR related blogs.