Antibodies

Prostate cancer is caused by malignant cells developing in prostate tissue. Common warning signs of prostate cancer include problems with urination (sudden urges, pain, blood in urine, difficulty urinating), experiencing pain in the back and pelvis, and feeling tired/dizzy. There are different tests utilized to diagnose prostate cancer including PSA screening, TRUS, DRE, and biopsy.

Breast cancer is caused by malignant cells developing in breast tissue. It is the most commonly diagnosed cancer in women, but advancements in treatment options have seen the death rate decline since the 1990s. Common warning signs of breast cancer include lumps, changes in breast size or shape, discoloration, dimpling of the skin, new concentrated pain in the breast, and rash on the nipple.  Yearly mammograms and self-exams are an important part of early detection of breast cancer.

The CXCR7 (C-X-C chemokine receptor type 7) proinflammatory protein is a member of the G-protein coupled receptor (GPCR) family. It is a transmembrane protein first identified as the EBV-induced gene-1, and while it was originally classified as an orphan receptor, it is now known to be a novel and alternate receptor for the chemokines CXCL11 and CXCL12.

After working on several thousand experiments to test products, rigorously quality testing data, and validating products in the lab at Novus Biologicals, we have developed a list of things that only scientists will understand from spending time in a lab. Happy April Fools' Day and enjoy our top 10 list!

By: Amelia Zommer, Sam Garcia, Andrew Cosgrove and Lisa Ikariyama

Beta-actin belongs to a large family of highly conserved structural cell proteins that regulate cell motility, structure, and integrity. Beta-actin is expressed in all eukaryotic cells making it the ideal internal quantitative control for protein comparative assays. This feature has made it uniquely a historical and heavily-utilized standard, as the public record of scientific publication literature can attest to.

RNA polymerase II is a large 12-subunit complex that synthesizes all mRNAs and several non-coding RNAs in eukaryotic cells. It is a DNA-dependent RNA polymerase enzyme that catalyzes transcription of DNA into RNA based on the four ribonucleoside triphosphate building blocks. RNA polymerase II is regulated through DNA-binding transcriptional regulators in both gene and cell type-specific manners.

Cells undergo apoptotic programmed cell death in response to various stimuli. The process is required for morphogenesis, tissue homeostasis, and host defense. Certain cytokines such as tumor necrosis factor (TNF) and Fas ligand signal through death domain-containing receptors such as tumor necrosis factor receptor 1 (TNFR1) and Fas.

Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells. It regulates RNA processing, trafficking and nascent pre-RNA metabolism, receptor-mediated signal transduction, and transcriptional activation processes. PRMT6 was originally identified through a genome-wide search for human protein arginine N-methyltransferase (PRMT) family members. This particular enzyme has type I PRMT activity and with regards to substrate specificity, is functionally distinct from two other previously characterized type I enzymes - PRMT1 and PRMT4.

The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 ligand works by modulating intracellular calcium ion levels and activating the MAPK1/MAPK3 signal pathways. CXCR4 is also a receptor for extracellular ubiquitin, which produces enhanced levels of intracellular calcium and reduced levels of cellular cAMP.

Nur77 is a member of the steroid/thyroid hormone phosphoprotein receptor superfamily. It is heavily post-translationally modified and rapidly induced in response to androgens and growth factors. It governs fundamental processes such as cell proliferation, differentiation, and apoptosis. For some time, it was classified as an orphan receptor with no identifiable or known ligand, but scientists finally were able to identify a novel class of methylene-substituted diindolylmethanes (C-DIM) as its endogenous ligand.