We at Novus Biologicals have over 230 products in our antibody catalog devoted to nucleotide excision repair. NER is a multi-stage sequential process involving over 30 proteins, all of which have been widely studied. Being the primary method to repair DNA damage caused by agents ranging from UV radiation to chemotherapy drugs, our NER antibody database is widely used by cancer research groups.
The mammalian DNA repair process encompasses a large number of protein pathways, and forms an important part of our antibody catalog. The past 30 years have seen tremendous advances in the understanding of these mechanisms, with Wood, et al. recently compiling an updated inventory of at least 150 human DNA-repair proteins. This added considerably to the scope of the antibody database of us at Novus Biologicals.
The typical way of detecting proteins by immunohistochemical staining involves a two-step process. A primary antibody is raised against the antigen, and then a second, fluorescently-labeled antibody is used to detect the first.
Dr. Randall Nelson and his Molecular Biomarkers Lab Team are the topic of this week's Novus Customer Focus. At Arizona State University's Biodesign Institute, Dr. Nelson and his lab conduct biomarker research to investigate and understand how biomarkers function and how they can be used in medical applications.
Novus Biologicals recently added a new PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene.
Veterinary research is a well established and growing field for studying animal reproduction, infectious disease, cancer and more. Research of vet species often requires the production and use of vet antibodies. Novus Biologicals provides an extensive line of antibodies for veterinary research. Novus' vet antibody line includes antibodies against many vet species, including bovine, canine, chicken, equine, feline, goat, porcine and sheep.
A large number of antibody suppliers supply conjugated and non-conjugated marker antibodies, targeted at specific stem cell populations. Until recently the number of oval stem cell markers was extremely limited. However, we at Novus Biologicals have succeeded in developing a new line of monoclonal antibodies specifically targeted to the murine oval cell response. These have just been added to our stem cell antibody database.
At Novus Biologicals, we recently added a new RNA Polymerase II antibody (clone 4H8) to our antibody catalog. RNAPII is an essential transcription enzyme, catalyzing the transcription of DNA during the elongation stage of mRNA synthesis (known as the RNA polymerase II elongation complex.) RNAPII transcription is commonly recognized as the primary site of gene expression in eukaryotes, and is the most studied of the RNA polymerase enzymes.
