Antibody News

We at Novus Biologicals have an extensive antibody catalog covering lipid and metabolism research, including Adiponectin and leptin antibody products.

Excess body fat is linked to many human diseases, including IRS (insulin resistance syndrome), type 2 diabetes, atherosclerosis and CAD (coronary artery disease). Fat cells were originally thought to be simple lipid storage vessels, but are now known to secrete several metabolically active hormones, called adipocytokines. These include TNF-alpha, IL-6, PAI-1, Resistin, Angiotensin, Adiponectin and leptin.

Human adiponectin accounts for around 0.01% of total plasma proteins. Our antibody catalog...

Interleukin 6 is a complex pleiotropic cytokine having both anti and pro-inflammatory effects. Alterations in expression contribute to many human diseases, and the IL6 antibody is widely used in the research areas of innate and adaptive immunity, autoimmune disorders; CAD (coronary artery disease); neurological disorders; cancer and inflammatory disease. We at Novus Biologicals are one of the leading antibody suppliers for interleukin research.

IL6 is secreted by a variety of cells including macrophages, monocytes, T-cells, fibroblasts, endothelial cells, and keratinocytes, in response to LPS, TNF alpha,...

Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1) is a single-pass membrane receptor also known as CD31 (cluster of differentiation 31.) CD31 is expressed at high levels at endothelial cell junctions, and therefore the CD31 antibody is widely used as an endothelial marker, one use being to measure the progression of angiogenesis following recurrence of tumors. Other CD31 antibody studies have suggested a possible use as a myeloid progenitor cell marker, and in the identification of different granular sarcoma subsets.

Novus Biologicals is constantly refining our CD31 antibody catalog to ensure customers have a wide range of reagents to choose from, covering as many assay applications as possible. In addition to standard monoclonals and polyclonals, our catalog also contains a variety of CD31 antibody reagents...

The matrix metalloproteinases are zinc-dependent protease enzymes which interact with a range of ECM (extracellular matrix) proteins, and are activated by proteolytic cleavage. We at Novus Biologicals offer a wide range of top quality MMP reagents, including MMP3, MMP7, MMP9, MMP13 and MMP2 specific antibodies.

All the above proteins are known to play important roles in embryonic development, wound healing, angiogenesis, carcinogenesis, tumour invasion and apoptosis. Overexpression of MMP2 and MMP9 is associated with tumour migration, metastasis and aggressive, invasive...

ATP-binding cassette superfamily F2 (ABCF2) is a member of the ATP-binding cassette (ABC) transporter superfamily, and more specifically, a member of the GCN20 subfamily. Most members of this family are membrane proteins that transport various substrates across the cell membrane [1, 2]. ABC genes have a pair of nucleotide binding folds (NBF) and trans-membrane (TM) domains; ABCF2 differs by having a pair of NBF’s but no TM domains.  It is this distinction that leads most researchers to believe that ABCF2 does not have any membrane transport function, but instead may be involved in translational control, antibiotic resistance, and RNase L inhibition [1, 3].

Areas of study that utilize the ABCF2 protein include breast cancer, cervical cancer,...

Apoptosis is one of the best-characterized phenomena in cellular and molecular biology. Not only is it essential for successful development, but its deregulation also leads to a number of human diseases, most notably cancer. The cysteine aspartate protease (caspase) family of proteins has been studied extensively over the past several decades and found to play a pivotal role in the execution of apoptosis; caspase activation is regarded as commitment to programmed cell death.  A variety of intrinsic and extrinsic stressors are capable of initiating mediated cell death, however, transduction commonly occurs via caspase activity.  Initiator caspases (8, 9, 10 and 2) are activated first, generally by binding oligomeric adaptor proteins, and subsequently activate the effector...

S100A6 antibodies detect a small calcium binding protein with 2 EF-hand structures and belongs to the S100 family. Calcium binding induces a conformational change of the protein which in turn permits its interaction with several target proteins. It is predominantly expressed in fibroblasts and epithelial cells and has been implicated in several cellular processes such as cell cycle progression, cytoskeleton rearrangement and exocytosis. It is a predominantly cytoplasmic protein however in the presence of calcium ions it might also associate with cell membranes.  Its vast array of biological processes may be due to the fact that it has the ability to bind a number of proteins and modulate their function by inducing conformation changes and/or interfering with post-translational modifications.

The upregulation of S100A6...

Methionine Adenosyltransferase II alpha, also known as MAT2a, is a catalytic subunit of methionine adenosyltransferase (MAT) and essential enzyme for the catalysis of the principle biological methyl donor, S-adenosylmethionine (SAM) from methionine and ATP. MAT2a's heterotetramer structure is composed of 2 catalytic alpha subunits (alpha and alpha’)¹. During development in the adult human liver, MAT2a and its gene products are progressively replaced by MAT1a during fetal liver development². Increased growth and malignant degenerations has been observed in hepatocytes expressing increased levels of MAT2a and MAT2b². It has been frequently observed in malignant liver transformation, that the expression of MAT1a is switched to MAT2a, which is believed to be an important factor in facilitating liver cancer progression³.

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The TUB gene, which encodes for the protein Tubby, is evolutionarily conserved in human, chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C. elegans, and rice.

The gene derives its name from its role in metabolism; mice with a mutated tubby gene develop delayed-onset obesity, sensorineural hearing loss and retinal degeneration (a syndrome known as the autosomal recessive syndrome “Tubby”)

The first tubby gene was identified in mice, and proteins that are homologous to tubby are known as "tubby-like proteins" (TULPs).

The identification of a mutation at the tubby (Tub) locus in mice, led to the discovery of the homologous tubby-like proteins (TULPs). Tub and the genes that encode for TULPs (...

P53 is a stress-activated transcription factor, encoded by the TP53 gene. An important tumor suppressor, the protein mediates cellular growth and proliferation, regulating proteins involved in the stress-response. In p53 antibody studies, the protein has been shown to play an important role in the cellular response to DNA damage. Activation of p53 in response to stress stimuli may promote either cell cycle arrest followed by DNA repair, or apoptosis. We at Novus Biologicals are major antibody suppliers of p53 research products.

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