RKIP/PBP Antibody

Images

 
Western Blot: PBP Antibody [NB110-93495] - Rat brain lysate showing the specific immunolabeling of the ~ 22k PEBP protein.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-93495
    • Availability
      Product Discontinued

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RKIP/PBP Antibody Summary

Immunogen
Purified native rat PEBP
Specificity
Specific for the 22k PEBP protein in Western blots.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PEBP1
Purity
Whole Antiserum
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Tested in Rat.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Neat serum
Preservative
No Preservative
Purity
Whole Antiserum

Alternate Names for RKIP/PBP Antibody

  • HCNP
  • HCNPpp
  • hippocampal cholinergic neurostimulating peptide
  • Neuropolypeptide h3
  • PBP
  • PBPPEBP-1
  • PEBP1
  • PEBP-1
  • PEBPHCNPpp
  • phosphatidylethanolamine binding protein 1
  • phosphatidylethanolamine-binding protein 1
  • prostatic binding protein
  • Prostatic-binding protein
  • Raf kinase inhibitory protein
  • RKIP
  • RKIPRaf kinase inhibitor protein

Background

Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer's disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PEBP1
Entrez
Uniprot