| Formulation | Catalog # | Availability | Price | |
|---|---|---|---|---|
| BSA Free | NBP1-02935SS | |||
| Formulation | Catalog # | Availability | Price | |
|---|---|---|---|---|
| Azide and BSA Free | NBP2-33152 | |||
| IHC-Prediluted | NBP2-48405 | |||
| Formulation | Catalog # | Availability | Price | |
|---|---|---|---|---|
| BSA Free | NB100-82001-0.025ml | |||
| Formulation | Catalog # | Availability | Price | |
|---|---|---|---|---|
| Azide and BSA Free | NB600-1004-20ug | |||
![Western Blot: ATF3 Antibody [NBP1-02935] - Western blot analysis of ATF3 on UV treated NIH/3T3 cell extracts using NBP1-02935.](http://images.novusbio.com/fullsize/ATF3-Antibody-Western-Blot-NBP1-02935-img0004.jpg "Western Blot: ATF3 Antibody [NBP1-02935] - Western blot analysis of ATF3 on UV treated NIH/3T3 cell extracts using NBP1-02935.")
![Immunohistochemistry: ATF3 Antibody [NBP1-02935] - Analysis of ATF3 in human prostate using Fast Red with hematoxylin counterstain.](http://images.novusbio.com/fullsize/ATF3-Antibody-Immunohistochemistry-NBP1-02935-img0002.jpg)
![Immunohistochemistry-Paraffin: Carbonic Anhydrase IX/CA9 Antibody (66.4.C2 (PN-15)) [NBP2-15199] - FFPE human renal cell carcinoma stained with RCC Ab (66.4.C2). Note cytoplasmic & cell surface staining of tumor cells.](http://images.novusbio.com/fullsize/Carbonic-Anhydrase-IX-CA9-Antibody-66-4-C2-PN-15-Immunohistochemistry-Paraffin-NBP2-15199-img0006.jpg "Immunohistochemistry-Paraffin: Carbonic Anhydrase IX/CA9 Antibody (66.4.C2 (PN-15)) [NBP2-15199] - FFPE human renal cell carcinoma stained with RCC Ab (66.4.C2). Note cytoplasmic & cell surface staining of tumor cells.")
![Western Blot: IRS1 Antibody [NB100-82001] - Analysis of extracts from 293 cells using NB100-82001](http://images.novusbio.com/fullsize/IRS1-Antibody-Western-Blot-NB100-82001-img0002.jpg "Western Blot: IRS1 Antibody [NB100-82001] - Analysis of extracts from 293 cells using NB100-82001")
![Immunocytochemistry/ Immunofluorescence: IRS1 Antibody - BSA Free [NB100-82001] - Immunofluorescence staining of methanol-fixed Hela cells using NB100-82001.](http://images.novusbio.com/fullsize/nb100-82001_rabbit-polyclonal-irs1-antibody-103202523464533.jpg)
![Immunohistochemistry-Paraffin: IRS1 Antibody [NB100-82001] - Analysis of breast carcinoma tissue, using NB100-82001(left) or the same antibody preincubated with blocking peptide(right).](http://images.novusbio.com/fullsize/nb100-82001_rabbit-polyclonal-irs1-antibody-103202523321013.jpg)
![Western Blot: VEGFR1/Flt-1 Antibody (Flt-1/EWC) [NB600-1004] - Analysis of recombinant human and mouse soluble VEGF receptors using a monoclonal antibody directed against human recombinant sFlt-1(D5). There is a cross reactivity with mouse sFlt-1(D7)-Fc but no with human and mouse sKDR and human sFLT-4 visible.](http://images.novusbio.com/fullsize/VEGFR1-Flt-1-Antibody-Flt-1-EWC-Western-Blot-NB600-1004-img0004.jpg "Western Blot: VEGFR1/Flt-1 Antibody (Flt-1/EWC) [NB600-1004] - Analysis of recombinant human and mouse soluble VEGF receptors using a monoclonal antibody directed against human recombinant sFlt-1(D5). There is a cross reactivity with mouse sFlt-1(D7)-Fc but no with human and mouse sKDR and human sFLT-4 visible.")
![Immunocytochemistry/Immunofluorescence: VEGFR1/Flt-1 Antibody (EWC) - Azide and BSA Free [NB600-1004] - VEGFR1/Flt-1 Antibody (Flt-1/EWC) [NB600-1004] - Staining of human Flt-1 in a co-culture of PAE-Flt-1, PAE-KDR and PAE-FLT-4 with a mouse anti-human Flt-1 antibody. Conjugated secondary antibody: goat anti-mouse ALEXA Flour (1:600).](http://images.novusbio.com/fullsize/VEGFR1-Flt-1-Antibody-Flt-1-EWC-Immunocytochemistry-Immunofluorescence-NB600-1004-img0007.jpg)
![Western Blot: VEGFR1/Flt-1 Antibody (Flt-1/EWC) [NB600-1004] - Analysis of recombinant mouse soluble VEGFR-1 conditioned supernatant using a monoclonal antibody directed against human recombinant sFlt-1(D5). There is a strong cross reactivity with the mouse sFlt-1 visible.](http://images.novusbio.com/fullsize/VEGFR1-Flt-1-Antibody-Flt-1-EWC-Western-Blot-NB600-1004-img0006.jpg)
![Western Blot: SP1 Antibody (1A5) [H00006667-M02] - SP1 monoclonal antibody (M02), clone 1A5 Analysis of SP1 expression in Hela S3 NE.](http://images.novusbio.com/fullsize/SP1-Antibody-1A5-Western-Blot-H00006667-M02-img0014.jpg "Western Blot: SP1 Antibody (1A5) [H00006667-M02] - SP1 monoclonal antibody (M02), clone 1A5 Analysis of SP1 expression in Hela S3 NE.")
![Immunocytochemistry/Immunofluorescence: SP1 Antibody (1A5) [H00006667-M02] - Analysis of monoclonal antibody to SP1 on HeLa cell. Antibody concentration 10 ug/ml.](http://images.novusbio.com/fullsize/SP1-Antibody-1A5-Immunocytochemistry-Immunofluorescence-H00006667-M02-img0008.jpg)
![Immunohistochemistry-Paraffin: SP1 Antibody (1A5) [H00006667-M02] - Analysis of monoclonal antibody to SP1 on formalin-fixed paraffin-embedded human colon. Antibody concentration 1 ug/ml.](http://images.novusbio.com/fullsize/SP1-Antibody-1A5-Immunohistochemistry-Paraffin-H00006667-M02-img0012.jpg)
![Western Blot: SP1 Antibody (1A5) [H00006667-M02] - SP1 monoclonal antibody (M02), clone 1A5. Analysis of SP1 expression in NIH/3T3.](http://images.novusbio.com/fullsize/SP1-Antibody-1A5-Western-Blot-H00006667-M02-img0015.jpg)
![Immunohistochemistry-Paraffin: SP1 Antibody (1A5) [H00006667-M02] - Analysis of monoclonal antibody to SP1 on formalin-fixed paraffin-embedded human endometrium. Antibody concentration 1 ug/ml.](http://images.novusbio.com/fullsize/SP1-Antibody-1A5-Immunohistochemistry-Paraffin-H00006667-M02-img0010.jpg)
![ELISA: SP1 Antibody (1A5) [H00006667-M02] - Detection limit for recombinant GST tagged SP1 is approximately 0.1ng/ml as a capture antibody.](http://images.novusbio.com/fullsize/SP1-Antibody-1A5-ELISA-H00006667-M02-img0016.jpg)
![ELISA: p62/SQSTM1 Antibody (1C9) [H00008878-M03] - Detection limit for recombinant GST tagged SQSTM1 is approximately 3ng/ml as a capture antibody.](http://images.novusbio.com/fullsize/p62-SQSTM1-Antibody-1C9-Sandwich-ELISA-H00008878-M03-img0002.jpg "ELISA: p62/SQSTM1 Antibody (1C9) [H00008878-M03] - Detection limit for recombinant GST tagged SQSTM1 is approximately 3ng/ml as a capture antibody.")
![Western Blot: CrkL Antibody (4B5) [H00001399-M03] - Analysis of CRKL expression in transfected 293T cell line by CRKL monoclonal antibody (M03), clone 4B5. Lane 1: CRKL transfected lysatE (33.8 KDa). Lane 2: Non-transfected lysate.](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-Western-Blot-H00001399-M03-img0008.jpg "Western Blot: CrkL Antibody (4B5) [H00001399-M03] - Analysis of CRKL expression in transfected 293T cell line by CRKL monoclonal antibody (M03), clone 4B5. Lane 1: CRKL transfected lysatE (33.8 KDa). Lane 2: Non-transfected lysate.")
![Immunocytochemistry/Immunofluorescence: CrkL Antibody (4B5) [H00001399-M03] - Analysis of protein-protein interactions between PTK2 and CRKL. Huh7 cells were stained with anti-PTK2 rabbit purified polyclonal 1:600 and anti-CRKL mouse monoclonal antibody 1:100. Each red dot represents the detection of protein-protein interaction com](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-Immunocytochemistry-Immunofluorescence-H00001399-M03-img0006.jpg)
![Western Blot: CrkL Antibody (4B5) [H00001399-M03] - Western blot analysis of CRKL over-expressed 293 cell line, cotransfected with CRKL Validated Chimera RNAi or non-transfected control. Blot probed with H00001399-M03. GAPDH (36.1 kDa) used as loading control.](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-Western-Blot-H00001399-M03-img0002.jpg)
![Immunocytochemistry/Immunofluorescence: CrkL Antibody (4B5) [H00001399-M03] - Analysis of monoclonal antibody to CRKL on HeLa cell. Antibody concentration 10 ug/ml](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-Immunocytochemistry-Immunofluorescence-H00001399-M03-img0004.jpg)
![Immunocytochemistry/Immunofluorescence: CrkL Antibody (4B5) [H00001399-M03] - Analysis of protein-protein interactions between GAB1 and CRKL. HeLa cells were stained with anti-GAB1 rabbit purified polyclonal 1:1200 and anti-CRKL mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction com](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-Immunocytochemistry-Immunofluorescence-H00001399-M03-img0005.jpg)
![ELISA: CrkL Antibody (4B5) [H00001399-M03] - Detection limit for recombinant GST tagged CRKL is approximately 0.3ng/ml as a capture antibody.](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-ELISA-H00001399-M03-img0003.jpg)
![Proximity Ligation Assay: CrkL Antibody (4B5) [H00001399-M03] - Analysis of protein-protein interactions between HCK and CRKL. Mahlavu cells were stained with anti-HCK rabbit purified polyclonal 1:1200 and anti-CRKL mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction co](http://images.novusbio.com/fullsize/CrkL-Antibody-4B5-Proximity-Ligation-Assay-H00001399-M03-img0007.jpg)
![Western Blot: Necdin Antibody (1B3) [H00004692-M02] - Analysis of NDN expression in transfected 293T cell line by NDN monoclonal antibody (M02), clone 1B3.Lane 1: NDN transfected lysate(36.1 KDa).Lane 2: Non-transfected lysate.](http://images.novusbio.com/fullsize/Necdin-Antibody-1B3-Western-Blot-H00004692-M02-img0014.jpg "Western Blot: Necdin Antibody (1B3) [H00004692-M02] - Analysis of NDN expression in transfected 293T cell line by NDN monoclonal antibody (M02), clone 1B3.Lane 1: NDN transfected lysate(36.1 KDa).Lane 2: Non-transfected lysate.")
![Immunocytochemistry/Immunofluorescence: Necdin Antibody (1B3) [H00004692-M02] - Analysis of monoclonal antibody to NDN on HeLa cell. Antibody concentration 10 ug/ml.](http://images.novusbio.com/fullsize/Necdin-Antibody-1B3-Immunocytochemistry-Immunofluorescence-H00004692-M02-img0008.jpg)
![Immunohistochemistry-Paraffin: Necdin Antibody (1B3) [H00004692-M02] - Analysis of monoclonal antibody to NDN on formalin-fixed paraffin-embedded human colon. Antibody concentration 1.5 ug/ml.](http://images.novusbio.com/fullsize/Necdin-Antibody-1B3-Immunohistochemistry-Paraffin-H00004692-M02-img0010.jpg)
![Western Blot: Necdin Antibody (1B3) [H00004692-M02] - Analysis of NDN over-expressed 293 cell line, cotransfected with NDN Validated Chimera RNAi ( Cat # H00004692-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with NDN monoclonal antibody (M02), clone 1B3 (Cat # H00004692-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.](http://images.novusbio.com/fullsize/Necdin-Antibody-1B3-Western-Blot-H00004692-M02-img0011.jpg)
![Western Blot: Necdin Antibody (1B3) [H00004692-M02] - NDN monoclonal antibody (M02), clone 1B3 Analysis of NDN expression in HL-60.](http://images.novusbio.com/fullsize/Necdin-Antibody-1B3-Western-Blot-H00004692-M02-img0013.jpg)
![ELISA: Necdin Antibody (1B3) [H00004692-M02] - Detection limit for recombinant GST tagged NDN is approximately 0.03ng/ml as a capture antibody.](http://images.novusbio.com/fullsize/Necdin-Antibody-1B3-ELISA-H00004692-M02-img0015.jpg)
![Western Blot: UGT1A9 Antibody [H00054600-B01P] - Analysis of UGT1A9 expression in human liver.](http://images.novusbio.com/fullsize/UGT1A9-Antibody-Western-Blot-H00054600-B01P-img0005.jpg "Western Blot: UGT1A9 Antibody [H00054600-B01P] - Analysis of UGT1A9 expression in human liver.")
![Immunohistochemistry-Paraffin: UGT1A9 Antibody [H00054600-B01P] - Analysis of purified antibody to UGT1A9 on formalin-fixed paraffin-embedded human small Intestine. (antibody concentration 3 ug/ml)](http://images.novusbio.com/fullsize/UGT1A9-Antibody-Immunohistochemistry-Paraffin-H00054600-B01P-img0004.jpg)
![Western Blot: UGT1A9 Antibody [H00054600-B01P] - Analysis of UGT1A9 expression in transfected 293T cell line by UGT1A9 polyclonal antibody. Lane 1: UGT1A9 transfected lysate(58.3 KDa). Lane 2: Non-transfected lysate.](http://images.novusbio.com/fullsize/UGT1A9-Antibody-Western-Blot-H00054600-B01P-img0006.jpg)
![Western Blot: RPS5 Antibody (4H3) [H00006193-M02] - Analysis of RPS5 expression in transfected 293T cell line by RPS5 monoclonal antibody (M02), clone 4H3.Lane 1: RPS5 transfected lysate(22.9 KDa).Lane 2: Non-transfected lysate.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-Western-Blot-H00006193-M02-img0014.jpg "Western Blot: RPS5 Antibody (4H3) [H00006193-M02] - Analysis of RPS5 expression in transfected 293T cell line by RPS5 monoclonal antibody (M02), clone 4H3.Lane 1: RPS5 transfected lysate(22.9 KDa).Lane 2: Non-transfected lysate.")
![Immunocytochemistry/Immunofluorescence: RPS5 Antibody (4H3) [H00006193-M02] - Analysis of monoclonal antibody to RPS5 on HeLa cell. Antibody concentration 10 ug/ml.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-Immunocytochemistry-Immunofluorescence-H00006193-M02-img0008.jpg)
![Western Blot: RPS5 Antibody (4H3) [H00006193-M02] - RPS5 monoclonal antibody (M02), clone 4H3 Analysis of RPS5 expression in HeLa.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-Western-Blot-H00006193-M02-img0010.jpg)
![Western Blot: RPS5 Antibody (4H3) [H00006193-M02] - RPS5 monoclonal antibody (M02), clone 4H3. Analysis of RPS5 expression in PC-12.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-Western-Blot-H00006193-M02-img0011.jpg)
![Western Blot: RPS5 Antibody (4H3) [H00006193-M02] - RPS5 monoclonal antibody (M02), clone 4H3. Analysis of RPS5 expression in Raw 264.7.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-Western-Blot-H00006193-M02-img0012.jpg)
![Western Blot: RPS5 Antibody (4H3) [H00006193-M02] - RPS5 monoclonal antibody (M02), clone 4H3. Analysis of RPS5 expression in NIH/3T3.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-Western-Blot-H00006193-M02-img0013.jpg)
![ELISA: RPS5 Antibody (4H3) [H00006193-M02] - Detection limit for recombinant GST tagged RPS5 is approximately 3ng/ml as a capture antibody.](http://images.novusbio.com/fullsize/RPS5-Antibody-4H3-ELISA-H00006193-M02-img0009.jpg)
![Western Blot: ROCK2 Antibody (1E12) [H00009475-M02] - ROCK2 monoclonal antibody (M02), clone 1E12 Analysis of ROCK2 expression in Hela S3 NE.](http://images.novusbio.com/fullsize/ROCK2-Antibody-1E12-Western-Blot-H00009475-M02-img0009.jpg "Western Blot: ROCK2 Antibody (1E12) [H00009475-M02] - ROCK2 monoclonal antibody (M02), clone 1E12 Analysis of ROCK2 expression in Hela S3 NE.")
![Immunocytochemistry/Immunofluorescence: ROCK2 Antibody (1E12) [H00009475-M02] - Analysis of monoclonal antibody to ROCK2 on HeLa cell. Antibody concentration 30 ug/ml.](http://images.novusbio.com/fullsize/ROCK2-Antibody-1E12-Immunocytochemistry-Immunofluorescence-H00009475-M02-img0005.jpg)
![Immunohistochemistry-Paraffin: ROCK2 Antibody (1E12) [H00009475-M02] - Analysis of monoclonal antibody to ROCK2 on formalin-fixed paraffin-embedded human small Intestine. Antibody concentration 1.5 ug/ml.](http://images.novusbio.com/fullsize/ROCK2-Antibody-1E12-Immunohistochemistry-Paraffin-H00009475-M02-img0007.jpg)
![Sandwich ELISA: ROCK2 Antibody (1E12) [H00009475-M02] - Detection limit for recombinant GST tagged ROCK2 is 0.3 ng/ml as a capture antibody.](http://images.novusbio.com/fullsize/ROCK2-Antibody-1E12-Sandwich-ELISA-H00009475-M02-img0008.jpg)
![Western Blot: Jagged 1 Antibody (1E12.) [H00000182-M01A] - Western Blot detection against Immunogen (35.64 KDa) .](http://images.novusbio.com/fullsize/Jagged-1-Antibody-1E12-Western-Blot-H00000182-M01A-img0001.jpg "Western Blot: Jagged 1 Antibody (1E12.) [H00000182-M01A] - Western Blot detection against Immunogen (35.64 KDa) .")
![<b>Genetic Strategies Validation. </b>Immunohistochemistry: Jagged 1 Antibody (1E12) [H00000182-M01A] - Jagged 1 regulates learning-dependent Notch induction and is enriched presynaptically. Fluorescent double-labeling shows the expression of Notch1 (red) following spatial exploration in CTLs and Jagged 1cKO. Jagged 1 labeling (green) is used to validate the absence of Jagged 1 in the Jagged 1cKO (Jag1cKOs). Image collected and cropped by CiteAb from the following publication (www.journal.frontiersin.org/article/10.3389/fncel.2017.00220/full) licensed under a CC-BY license.](http://images.novusbio.com/fullsize/Jagged-1-Antibody-1E12-Knockout-Validated-H00000182-M01A-img0002.jpg)
![Immunocytochemistry/ Immunofluorescence: Jagged 1 Antibody (1E12) [H00000182-M01A] - Targeted loss of Jagged1 in adult mouse neurons causes a spatial memory deficit. A schematic representation of the Jagged1 floxed allele used to generate the mice with TAM-inducible loss of Jagged1 gene (A). Representative immunofluorescence images of single confocal z-plane showing a near complete loss of Jagged1 protein (green) from hippocampal pyramidal neurons labeled by NeuN (red) of Jagged1cKO mice (B). Representative images from immunoblots showing the expression of Jagged1, DNER in Jagged1cKO mice & control mice (C). GAPDH is used as a loading control. Bar graph showing the quantitation of optical densities of Jagged1 & DNER bands in CTLs & Jagged1cKO mice (D). A graphic showing the behavioral arena for Y-maze spontaneous alternation test (E). Jagged1cKO mice show a significant deficit in hippocampus dependent working memory in the Y-maze spontaneous alternation test (F). A diagram showing the experimental arena for the hidden arm version of the Y-maze (G). Jagged1cKO mice show a significant reduction in the time spent in the hidden arm, suggesting a spatial memory defect (H). A schematic showing the experimental setup for the Novel Object Displacement test (I). Jagged1cKO mice exhibit a statistical significant reduction in discrimination index, a measure of spatial memory defect (J). Scale bar in (B) is 50 μm. Graphs are represented as mean ± SEM, *p < 0.05, **p < 0.01, & ***p < 0.001. Image collected & cropped by CiteAb from the following publication (//journal.frontiersin.org/article/10.3389/fncel.2017.00220/full), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/h00000182-m01a_mouse-monoclonal-jagged-1-antibody-1e12-310202415485115.jpg)
![Immunocytochemistry/ Immunofluorescence: Jagged 1 Antibody (1E12) [H00000182-M01A] - Jagged1 regulates learning-dependent Notch induction & is enriched presynaptically. Fluorescent double-labeling shows the expression of Notch1 (red) following spatial exploration in CTLs & Jagged1cKO (A). Jagged1 labeling (green) is used to validate the absence of Jagged1 in the Jagged1cKO (Jag1cKOs) (A,C). Diagram summarizing the Notch1 fluorescence intensities distribution in randomly picked 69 & 71 CA1 neurons in CTLs & Jagged1cKOs, respectively (p < 0.001) (B). Double immunofluorescence of the Notch1 transcriptional target, Hes5, in CTLs & JaggedcKOs following spatial exploration (C). Diagram summarizing the Hes5 fluorescence intensity distribution in randomly picked 64 & 70 CA1 neurons in CTL & Jagged1cKO, respectively (p < 0.001) (D). Representatives gold Immuno-electron microscopy panels from three WT mice show that Jagged1 particles are localized in presynaptic terminals, bound to presynaptic vesicles (Pre) (E–E‴). Immunogold particles are also apparent at the Postsynaptic density (Post) (E,E″,E‴). Box Plot summarizing the particle counts in presynaptic & postsynaptic terminal areas drawn on Immunoelectromicroscopy micrograph for Jagged1 indicates that the presynapse is enriched with Jag1 particles as compared to the postsynaptic terminal (p < 0.001) (F). Scale bars are: 20 μm in (A), 10 μm in (C), 400 nm in (E–E‴). AU, arbitrary units; Pre, presynaptic; Post, postsynaptic; & Ax, axon. Image collected & cropped by CiteAb from the following publication (//journal.frontiersin.org/article/10.3389/fncel.2017.00220/full), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/h00000182-m01a_mouse-monoclonal-jagged-1-antibody-1e12-310202415483644.jpg)
![Immunocytochemistry/ Immunofluorescence: Jagged 1 Antibody (1E12) [H00000182-M01A] - Jagged1 expression in brains & CSF of AD patients. Representative double fluorescent immunolabelings for Jagged1 (green) & Notch1 (red) counterstained with Thioflavin-T or DAPI (blue) on postmortem brain sections comprising the hippocampal CA fields from healthy age-matched controls & AD patients (A–C). in healthy controls, Jagged1 is localized to somata of neurons where also Notch1 is expressed. As expected, Thioflavin-T labeling is negligible (A,A′). AD sections show fibrillary aggregates (B,B′) & (C,C′) core plaques double positive for Notch1 & Thioflavin-T. Jag1 expression is scattered in parenchyma & low in, degenerated neurons (white arrows) (B,B′). Jag1 overlays in small double positive aggregates for Notch1 & Thioflavin-T (100x magnification) in radiating plaques with a visible reduction in Jagged1 cellular expression (B–C′). Box plots summarizing the quantification of fluorescence intensities of Jagged1 immunolabeled neurons shows a significant reduction in Jagged1 expression in AD patients (p < 0.001). Image collected & cropped by CiteAb from the following publication (//journal.frontiersin.org/article/10.3389/fncel.2017.00220/full), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/h00000182-m01a_mouse-monoclonal-jagged-1-antibody-1e12-310202415485139.jpg)
![Immunocytochemistry/ Immunofluorescence: Jagged 1 Antibody (1E12) [H00000182-M01A] - Jagged1 expression in brains & CSF of AD patients. Representative double fluorescent immunolabelings for Jagged1 (green) & Notch1 (red) counterstained with Thioflavin-T or DAPI (blue) on postmortem brain sections comprising the hippocampal CA fields from healthy age-matched controls & AD patients (A–C). in healthy controls, Jagged1 is localized to somata of neurons where also Notch1 is expressed. As expected, Thioflavin-T labeling is negligible (A,A′). AD sections show fibrillary aggregates (B,B′) & (C,C′) core plaques double positive for Notch1 & Thioflavin-T. Jag1 expression is scattered in parenchyma & low in, degenerated neurons (white arrows) (B,B′). Jag1 overlays in small double positive aggregates for Notch1 & Thioflavin-T (100x magnification) in radiating plaques with a visible reduction in Jagged1 cellular expression (B–C′). Box plots summarizing the quantification of fluorescence intensities of Jagged1 immunolabeled neurons shows a significant reduction in Jagged1 expression in AD patients (p < 0.001). Image collected & cropped by CiteAb from the following publication (//journal.frontiersin.org/article/10.3389/fncel.2017.00220/full), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/h00000182-m01a_mouse-monoclonal-jagged-1-antibody-1e12-310202415482294.jpg)