Recombinant Human UBE2K/E2-25K Protein

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SDS-Page: Human UBE2K/E2-25K His Protein [NBP2-35096]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func, PAGE
Format
Carrier-Free

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Catalog# & Formulation Size Price

Recombinant Human UBE2K/E2-25K Protein Summary

Description
A single, non-glycosylated biologically active polypeptide chain corresponding to 200 residues of UBE2K with an N-terminal His-Tag.

Source: E. coli

Amino Acid Sequence: MHHHHHHAMA NIAVQRIKRE FKEVLKSEET SKNQIKVDLV DENFTELRGE IAGPPDTPYE GGRYQLEIKI PETYPFNPPK VRFITKIWHP NISSVTGAIC LDILKDQWAA AMTLRTVLLS LQALLAAAEP DDPQDAVVAN QYKQNPEMFK QTARLWAHVY AGAPVSSPEY TKKIENLCAM GFDRNAVIVA LSSKSWDVET ATELLLSN

Preparation
Method
Novus' biologically active proteins are stringently purified to provide only the safest and most highly effective proteins available. This protein was expressed in E. coli, purified by HPLC, QC tested by SDS-PAGE and Western Blot and validated on appropriate cell lines for bioactivity. All HPLC and bioactivity data is provided for your assurance.
Source
E. coli
Protein/Peptide Type
Biologically Active Protein
Gene
UBE2K
Purity
>95% pure by SDS-PAGE
Endotoxin Note
Less than 1EU/ug of endotoxin as determined by LAL method.

Applications/Dilutions

Theoretical MW
23.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered concentrated solution in 50 mM HEPES, pH 8.0, with 100 mM NaCl, 10 % Glycerol, 5 % Trehalose, 1 mM DTT.
Preservative
5% Trehalose
Purity
>95% pure by SDS-PAGE
Reconstitution Instructions
Please contact technical support for detailed reconstitution instructions.

Alternate Names for Recombinant Human UBE2K/E2-25K Protein

  • E2(25K)
  • E225K
  • E2-25K
  • EC 6.3.2.19
  • Hip2
  • HIP-2
  • huntingtin interacting protein 2
  • Huntingtin-interacting protein 2
  • HYPG
  • LIG
  • UbcH1
  • UBE2K
  • UBE2K-25K
  • ubiquitin carrier protein
  • ubiquitin-conjugating enzyme E2 K
  • Ubiquitin-conjugating enzyme E2(25K)
  • Ubiquitin-conjugating enzyme E2-25 kDa
  • Ubiquitin-conjugating enzyme E2-25K
  • ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
  • ubiquitin-protein ligase

Background

Ubiquitin-conjugating enzyme E2 K (UBE2K) is a protein that in humans is encoded by the UBE2K gene. The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Bioinformatics

Gene Symbol UBE2K
Entrez
Uniprot