Species: Hu, Mu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Xp
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: PAGE
Description
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
3093 |
| Alternate Names |
- E2(25K)
- E225K
- E2-25K
- EC 6.3.2.19
- Hip2
- HIP-2
- huntingtin interacting protein 2
- Huntingtin-interacting protein 2
- HYPG
- LIG
- UbcH1
- UBE2K
- UBE2K-25K
- ubiquitin carrier protein
- ubiquitin-conjugating enzyme E2 K
- Ubiquitin-conjugating enzyme E2(25K)
- Ubiquitin-conjugating enzyme E2-25 kDa
- Ubiquitin-conjugating enzyme E2-25K
- ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
- ubiquitin-protein ligase
|
