UbcH2/UBE2H Antibody

Product Discontinued

UbcH2/UBE2H Antibody Summary

• Additional Information: Product is in the process of being discontinued.
• Immunogen: Full-length, highly purified human UbcH2 protein
• Specificity: Detects UbcH2/UBE2H in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: UBE2H

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store unopened vial at -80°C. Avoid repeated freeze-thaw cycles. Aliquot antibody in small volumes prior to freezing.
• Buffer: Supplied in a solution of PBS and Glycerol.
• Preservative: No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for UbcH2/UBE2H Antibody

• E2-14K
• E2-20K
• EC 6.3.2.19
• UBC8
• UBC8E2-20K
• UBCH
• UbcH2
• UBE2H
• Ubiquitin carrier protein H
• ubiquitin-conjugating enzyme E2 H
• Ubiquitin-conjugating enzyme E2-20K
• ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8)
• ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
• Ubiquitin-protein ligase H

Background

The UbcH2 enzyme encodes for the human homolog of the yeast Ubc8.  UbcH2 can conjugate ubiquitin to histone H2A in an E3-independent manner in vitro, and is essential for the multi-ubiquitination and degradation of N-end rule substrates.  Additionally, UbcH2 may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for UbcH2/UBE2H Antibody (A-605)(1)

Publication using A-605

• MC Yen, KL Wu, YW Liu, YY Chang, CY Chang, JY Hung, YM Tsai, YL Hsu Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma Biology, 2021-04-28;10(5):. 2021-04-28 [PMID: 33924823] (Western Blot, Human)

Bioinformatics

• Gene Symbol: UBE2H