Tryptase alpha/beta 1 Antibody [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 488

Tryptase alpha/beta 1 Antibody [Alexa Fluor™ Plus 488] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Tryptase alpha /TPS1
• Specificity: Detects human Tryptase alpha /TPS1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 60% cross‑reactivity with recombinant human (rh) TPSB2 is observed and 10% cross-reactivity with rhTPSG1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tryptase alpha/beta 1 Antibody [Alexa Fluor™ Plus 488]

• alpha-Tryptase
• EC:3.4.21.59
• epididymis secretory sperm binding protein
• mast cell alpha II tryptase
• mast cell beta I tryptase
• mast cell tryptase
• TPS1
• TPS2
• TPSAB1
• TPSB1
• TPSB2
• Tryptase 1
• tryptase alpha II
• Tryptase alpha
• Tryptase alpha-1
• tryptase beta I
• tryptase beta-1
• Tryptase beta-2
• Tryptase I
• tryptase II
• tryptase-1
• tryptase-2
• tryptase-I
• tryptase-III

Background

Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase beta-1, also known as mast cell protease 7 (MCPT7), exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. Tryptase epsilon, also known as brain-specific serine protease 4 (BSSP-4) and brain serine protease 2 (BSP-2), is encoded by the PRSS22 gene and preferentially expressed in epithelium-rich tissues such as lung and eye. Tryptase gamma-1, also called transmembrane tryptase, is encoded by TPSG1, one of many serine protease genes clustered on human chromosome 16p13.3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.