TfR2 Antibody (353810) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 353810
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

TfR2 Antibody (353810) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human TfR2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TfR2 Antibody (353810) [Alexa Fluor™ Plus 647]

• HFE3
• HFE3transferrin receptor protein 2
• MGC126368
• TfR2
• TFRC2
• transferrin receptor 2

Background

Transferrin Receptor 2 (TfR2) is an iron-binding protein that is homologous to the transferrin receptor. Lack of active TfR2 has been associated with a rare form of hemochromatosis. The TfR2 alpha isoform is a type 2 transmembrane protein that is expressed in the liver and modulates hepcidin production in response to iron. It forms a 215 kDa disulfide-linked homodimer that is presumably glycated. The TfR2 beta isoform lacks the intracellular, transmembrane and part of the extracellular regions and is expressed ubiquitously. The extracellular portion of human TfR2 shares 86% aa identity with mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.