TCR gamma/delta Antibody (TCR1) [Biotin]

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Product Details

Summary
Reactivity Ch, ReSpecies Glossary
Applications Flow, IHC, IHC-Fr, IHC-P, In vitro, IP
Clone
TCR1
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

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TCR gamma/delta Antibody (TCR1) [Biotin] Summary

Immunogen
Outbred chicken thymocytes and Ig-negative blood lymphocytes
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TRG
Purity
Protein A or G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry <= 1 ug/10^6 cells
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • In vitro assay
Readout System

Reactivity Notes

Chicken

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Protect conjugated forms from light.

Alternate Names for TCR gamma/delta Antibody (TCR1) [Biotin]

  • CD3d
  • delta polypeptide
  • T cell receptor gamma locus
  • T3D
  • T-cell antigen receptor, gamma polypeptide
  • T-cell rearranging gene, gamma
  • T-cell receptor, gamma cluster
  • TCR gamma/delta
  • TCRG
  • TiT3
  • TRG

Background

MAb TCR1 precipitates a heterodimer of Mr 90-kDa (two bands of Mr 40-kDa and 50-kDa upon reduction) on chicken peripheral blood T cells. (1,2) Deglycosylation of the heterodimer yields two polypeptides of Mr 35-kDa and 32-kDa from TCR1 precipitates. Unlike human and mouse, in which gamma delta cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of gamma delta T cells. (1-3) The frequency of TCR gamma delta cells is usually 20-25% of the total blood T cells, but may reach approximately 50% in chickens of 6 months of age. (2) The majority of TCR gamma delta+ cells in the thymus and blood are CD4-CD8-, although a small subset of them may express CD8 or CD4 coreceptors. (3) However, when the TCR gamma delta+ cells migrate into the spleen and intestine, most of them begin to express CD8. Although the biological function of gamma delta T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ gamma delta T cells may also be involved in down-regulation of the immune response. (4) They cannot, however, induce a graft-vs-host (GVH) reactions. (5)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

FITC Labeled NBP1-28276
PerCP Labeled NBP1-28275PCP

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TCR gamma/delta NBP1-28277

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Bioinformatics

Gene Symbol TRG
Entrez