TCR gamma/delta Products


MAb TCR1 precipitates a heterodimer of Mr 90-kDa (two bands of Mr 40-kDa and 50-kDa upon reduction) on chicken peripheral blood T cells. (1,2) Deglycosylation of the heterodimer yields two polypeptides of Mr 35-kDa and 32-kDa from TCR1 precipitates. Unlike human and mouse, in which gamma delta cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of gamma delta T cells. (1-3) The frequency of TCR gamma delta cells is usually 20-25% of the total blood T cells, but may reach approximately 50% in chickens of 6 months of age. (2) The majority of TCR gamma delta+ cells in the thymus and blood are CD4-CD8-, although a small subset of them may express CD8 or CD4 coreceptors. (3) However, when the TCR gamma delta+ cells migrate into the spleen and intestine, most of them begin to express CD8. Although the biological function of gamma delta T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ gamma delta T cells may also be involved in down-regulation of the immune response. (4) They cannot, however, induce a graft-vs-host (GVH) reactions. (5)


Entrez Mouse
Product By Gene ID 6965
Alternate Names
  • TRG
  • T-cell rearranging gene, gamma
  • T-cell antigen receptor, gamma polypeptide
  • T-cell receptor, gamma cluster
  • TCRG
  • T cell receptor gamma locus

Pathways for TCR gamma/delta

View related products by pathway and learn more about each of the pathways below.


Bioinformatics Tool for TCR gamma/delta

Discover related pathways, diseases and genes to TCR gamma/delta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.