Syntaxin-BP2 Antibody [Alexa Fluor® 750]

• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 750

Syntaxin-BP2 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Syntaxin‑BP2
  Glu81-Thr223
  Accession # NP_001120868
• Specificity: Detects human Syntaxin‑BP2 in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross‑reactivity with recombinant human (rh) Syntaxin-BP1 and rhSyntaxin-BP3 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Syntaxin‑BP2 (STXBP2; Syntaxin-binding protein 2; also Unc18-2 and Unc18B) is a 64‑66 kDa member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is widely expressed, particularly in hematopoietic cells, and is found both in cytoplasm, and associated with membranes, where it binds to STX1A, 2, and 3. Thus, it presumably participates in primary granule exocytosis by promoting granule fusion. Human STXBP2 is 593 amino acids (aa) in length. It contains one SEC1 domain (aa 28‑576) with Trp28, Ser42, and Glu59 all playing a key role in syntaxin binding. There is one splice variant that shows a deletion of aa 83‑85. Over aa 80‑223, human and mouse STXBP2 share 95% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.